6BVB
| Crystal structure of HIF-2alpha-pVHL-elongin B-elongin C | Descriptor: | Elongin-B, Elongin-C, Hypoxia-Inducible Factor 2 alpha, ... | Authors: | Tarade, D, Ohh, M, Lee, J.E. | Deposit date: | 2017-12-12 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | HIF-2 alpha-pVHL complex reveals broad genotype-phenotype correlations in HIF-2 alpha-driven disease. Nat Commun, 9, 2018
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6BWQ
| LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with MnCTP | Descriptor: | CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Fellner, M, Hausinger, R.P, Hu, J. | Deposit date: | 2017-12-15 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
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6BX7
| Crystal Structure of Human Protocadherin-1 EC1-4 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, Protocadherin-1 | Authors: | Modak, D, Sotomayor, M. | Deposit date: | 2017-12-17 | Release date: | 2018-12-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Identification of an adhesive interface for the non-clustered delta 1 protocadherin-1 involved in respiratory diseases. Commun Biol, 2, 2019
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6C8F
| Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of cesium | Descriptor: | CESIUM ION, Transient receptor potential cation channel, subfamily V, ... | Authors: | Deng, Z, Paknejad, N, Maksaev, G, Sala-Rabanal, M, Nichols, C.G, Hite, R.K, Yuan, P. | Deposit date: | 2018-01-24 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6.5 Å) | Cite: | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat. Struct. Mol. Biol., 25, 2018
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3ZET
| Structure of a Salmonella typhimurium YgjD-YeaZ heterodimer. | Descriptor: | ADENOSINE MONOPHOSPHATE, CADMIUM ION, PROBABLE TRNA THREONYLCARBAMOYLADENOSINE BIOSYNTHESIS PROTEIN GCP, ... | Authors: | Nichols, C.E, Lamb, H.K, Thompson, P, El Omari, K, Lockyer, M, Charles, I, Hawkins, A.R, Stammers, D.K. | Deposit date: | 2012-12-07 | Release date: | 2013-03-20 | Last modified: | 2013-05-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal Structure of the Dimer of Two Essential Salmonella Typhimurium Proteins, Ygjd & Yeaz and Calorimetric Evidence for the Formation of a Ternary Ygjd-Yeaz-Yjee Complex. Protein Sci., 22, 2013
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6BWO
| LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, apo form | Descriptor: | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein | Authors: | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | Deposit date: | 2017-12-15 | Release date: | 2018-06-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
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6BWV
| Crystal Structure of the 4-1BB/4-1BBL Complex | Descriptor: | DI(HYDROXYETHYL)ETHER, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | Authors: | Oganesyan, V, Gilbreth, R.N, Baca, M. | Deposit date: | 2017-12-15 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the human 4-1BB/4-1BBL complex. J. Biol. Chem., 293, 2018
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6BZW
| Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33 | Descriptor: | AP33 GL Heavy Chain, AP33 GL Light Chain, E2 AS412 peptide | Authors: | Tzarum, N, Aleman, F, Wilson, I.A, Law, M. | Deposit date: | 2017-12-26 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BXO
| Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAH | Descriptor: | Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E. | Deposit date: | 2017-12-18 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.655 Å) | Cite: | Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359, 2018
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6C2W
| Crystal structure of human prothrombin mutant S101C/A470C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... | Authors: | Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. | Deposit date: | 2018-01-09 | Release date: | 2018-02-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (4.12 Å) | Cite: | Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
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6BZU
| Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 | Descriptor: | 19B3 Heavy Chain, 19B3 Light Chain, E2 AS412 peptide | Authors: | Tzarum, N, Aleman, F, Kong, L, Wilson, I.A, Law, M. | Deposit date: | 2017-12-26 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BZY
| Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the 22D11 broadly neutralizing antibody | Descriptor: | 22D11 Heavy Chain, 22D11 Light Chain, E2 AS412 peptide | Authors: | Tzarum, N, Aleman, F, Wilson, I.A, Law, M. | Deposit date: | 2017-12-26 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6C1V
| MBD2 in complex with double-stranded DNA | Descriptor: | 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-01-05 | Release date: | 2018-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
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6C7Z
| Crystal structure of the Q108K:K40L:T51V:R58F mutant of human Cellular Retinol Binding Protein II in complex with synthetic Ligand Julolidine | Descriptor: | (2E,4E)-3-methyl-5-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)penta-2,4-dienal, ACETATE ION, Retinol-binding protein 2 | Authors: | Nosrati, M, Geiger, J.H. | Deposit date: | 2018-01-23 | Release date: | 2018-04-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | A Genetically Encoded Ratiometric pH Probe: Wavelength Regulation-Inspired Design of pH Indicators. Chembiochem, 19, 2018
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1JTN
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6BOM
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3ZQ6
| ADP-ALF4 COMPLEX OF M. THERM. TRC40 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Sherrill, J, Mariappan, M, Dominik, P, Hegde, R.S, Keenan, R.J. | Deposit date: | 2011-06-08 | Release date: | 2011-06-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion. Traffic, 12, 2011
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6BQH
| Crystal structure of 5-HT2C in complex with ritanserin | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, ... | Authors: | Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z. | Deposit date: | 2017-11-27 | Release date: | 2018-02-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172, 2018
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7STF
| Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ... | Authors: | Wright, K.M, Gabelli, S.B, Miller, M. | Deposit date: | 2021-11-12 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nat Commun, 14, 2023
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6BV8
| Structure of proteinaceous RNase P 1 (PRORP1) from A. thaliana complexed with Mn after 3-hour soak with juglone | Descriptor: | 5-hydroxynaphthalene-1,4-dione, CHLORIDE ION, MANGANESE (II) ION, ... | Authors: | Karasik, A, Wu, N, Fierke, C.A, Koutmos, M. | Deposit date: | 2017-12-12 | Release date: | 2019-06-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inhibition of protein-only RNase P with Gambogic acid and Juglone To Be Published
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7TA8
| NMR structure of crosslinked cyclophilin A | Descriptor: | Peptidyl-prolyl cis-trans isomerase A | Authors: | Lu, M, Toptygin, D, Xiang, Y, Shi, Y, Schwieters, C.D, Lipinski, E.C, Ahn, J, Byeon, I.-J.L, Gronenborn, A.M. | Deposit date: | 2021-12-20 | Release date: | 2022-06-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Magic of Linking Rings: Discovery of a Unique Photoinduced Fluorescent Protein Crosslink. J.Am.Chem.Soc., 144, 2022
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7T4V
| Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4W
| Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4T
| Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4U
| Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic acid, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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