7STF

Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2

Summary for 7STF

Entry DOI	10.2210/pdb7stf/pdb
EMDB information	25427
Descriptor	IgG, Fab Heavy Chain V2, KRAS G12V (7-16), IgG, Fab Light Chain V2, ... (5 entities in total)
Functional Keywords	complex, mhc-i, kras, hla-a3, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	92139.32
Authors	Wright, K.M.,Gabelli, S.B.,Miller, M. (deposition date: 2021-11-12, release date: 2023-05-31, Last modification date: 2023-10-25)
Primary citation	Wright, K.M.,DiNapoli, S.R.,Miller, M.S.,Aitana Azurmendi, P.,Zhao, X.,Yu, Z.,Chakrabarti, M.,Shi, W.,Douglass, J.,Hwang, M.S.,Hsiue, E.H.,Mog, B.J.,Pearlman, A.H.,Paul, S.,Konig, M.F.,Pardoll, D.M.,Bettegowda, C.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Zhou, S.,Gabelli, S.B. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nat Commun, 14:5063-5063, 2023 Cited by PubMed: 37604828 DOI: 10.1038/s41467-023-40821-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.14 Å)

Structure validation