7STF
Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2
Summary for 7STF
Entry DOI | 10.2210/pdb7stf/pdb |
EMDB information | 25427 |
Descriptor | IgG, Fab Heavy Chain V2, KRAS G12V (7-16), IgG, Fab Light Chain V2, ... (5 entities in total) |
Functional Keywords | complex, mhc-i, kras, hla-a3, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 92139.32 |
Authors | Wright, K.M.,Gabelli, S.B.,Miller, M. (deposition date: 2021-11-12, release date: 2023-05-31, Last modification date: 2023-10-25) |
Primary citation | Wright, K.M.,DiNapoli, S.R.,Miller, M.S.,Aitana Azurmendi, P.,Zhao, X.,Yu, Z.,Chakrabarti, M.,Shi, W.,Douglass, J.,Hwang, M.S.,Hsiue, E.H.,Mog, B.J.,Pearlman, A.H.,Paul, S.,Konig, M.F.,Pardoll, D.M.,Bettegowda, C.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Zhou, S.,Gabelli, S.B. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nat Commun, 14:5063-5063, 2023 Cited by PubMed: 37604828DOI: 10.1038/s41467-023-40821-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.14 Å) |
Structure validation
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