6BZY

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the 22D11 broadly neutralizing antibody

Summary for 6BZY

Entry DOI	10.2210/pdb6bzy/pdb
Descriptor	22D11 Heavy Chain, 22D11 Light Chain, E2 AS412 peptide, ... (4 entities in total)
Functional Keywords	hepatitis c virus, immune system, antibodies, broadly neutralizing antibodies, rational vaccine design, as412, e2, viral protein
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	49076.70
Authors	Tzarum, N.,Aleman, F.,Wilson, I.A.,Law, M. (deposition date: 2017-12-26, release date: 2018-06-20, Last modification date: 2023-10-04)
Primary citation	Aleman, F.,Tzarum, N.,Kong, L.,Nagy, K.,Zhu, J.,Wilson, I.A.,Law, M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc. Natl. Acad. Sci. U.S.A., 115:7569-7574, 2018 Cited by PubMed: 29954862 DOI: 10.1073/pnas.1802378115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation