6WGH
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![BU of 6wgh by Molmil](/molmil-images/mine/6wgh) | |
6WS4
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![BU of 6ws4 by Molmil](/molmil-images/mine/6ws4) | Crystal structure of KRAS-G12D/K104Q mutant, GDP-bound | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tran, T.H, Simanshu, D.K. | Deposit date: | 2020-04-30 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Res., 2023
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6WS2
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6XGU
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![BU of 6xgu by Molmil](/molmil-images/mine/6xgu) | Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | Descriptor: | GLYCEROL, GTPase KRas, MAGNESIUM ION, ... | Authors: | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XI7
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![BU of 6xi7 by Molmil](/molmil-images/mine/6xi7) | Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form I) | Descriptor: | CHLORIDE ION, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | Authors: | Chan, A.H, Tran, T.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-06-19 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XGV
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![BU of 6xgv by Molmil](/molmil-images/mine/6xgv) | Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | Descriptor: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | Authors: | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XHB
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![BU of 6xhb by Molmil](/molmil-images/mine/6xhb) | Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) | Descriptor: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | Authors: | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XHA
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![BU of 6xha by Molmil](/molmil-images/mine/6xha) | Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | Descriptor: | CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ... | Authors: | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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2HTA
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![BU of 2hta by Molmil](/molmil-images/mine/2hta) | Crystal Structure of a putative mutarotase (YeaD) from Salmonella typhimurium in orthorhombic form | Descriptor: | GLYCEROL, Putative enzyme related to aldose 1-epimerase, SULFATE ION | Authors: | Chittori, S, Simanshu, D.K, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2006-07-25 | Release date: | 2007-01-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the putative mutarotase YeaD from Salmonella typhimurium: structural comparison with galactose mutarotases. Acta Crystallogr.,Sect.D, 63, 2007
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2HTB
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![BU of 2htb by Molmil](/molmil-images/mine/2htb) | Crystal Structure of a putative mutarotase (YeaD) from Salmonella typhimurium in monoclinic form | Descriptor: | Putative enzyme related to aldose 1-epimerase | Authors: | Chittori, S, Simanshu, D.K, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2006-07-25 | Release date: | 2007-01-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the putative mutarotase YeaD from Salmonella typhimurium: structural comparison with galactose mutarotases. Acta Crystallogr.,Sect.D, 63, 2007
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2E7R
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![BU of 2e7r by Molmil](/molmil-images/mine/2e7r) | Crystal structure of Glu54 to Arg mutant of Diphthine synthase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-01-12 | Release date: | 2007-07-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3 To be Published
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2EGL
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![BU of 2egl by Molmil](/molmil-images/mine/2egl) | Crystal structure of Glu171 to Lys mutant of Diphthine synthase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-01 | Release date: | 2007-09-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3 To be Published
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2EGS
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![BU of 2egs by Molmil](/molmil-images/mine/2egs) | Crystal structure of Leu261 to Met mutant of Diphthine synthase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-02 | Release date: | 2007-09-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3 To be Published
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2EGB
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![BU of 2egb by Molmil](/molmil-images/mine/2egb) | Crystal structure of Glu140 to Asn mutant of Diphthine synthase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-02-28 | Release date: | 2007-08-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3 To be Published
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4NGD
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![BU of 4ngd by Molmil](/molmil-images/mine/4ngd) | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution) | Descriptor: | 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', DI(HYDROXYETHYL)ETHER, Endoribonuclease Dicer, ... | Authors: | Tian, Y, Simanshu, D.K, Patel, D.J. | Deposit date: | 2013-11-01 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.958 Å) | Cite: | A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
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4NH5
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5KDI
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![BU of 5kdi by Molmil](/molmil-images/mine/5kdi) | How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold | Descriptor: | (~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide, Pleckstrin homology domain-containing family A member 8 | Authors: | Ochoa-Lizarralde, B, Popov, A.N, Samygina, V.R, Patel, D.J, Brown, R.E, Malinina, L. | Deposit date: | 2016-06-08 | Release date: | 2017-12-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family. J.Biol.Chem., 293, 2018
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6IEJ
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![BU of 6iej by Molmil](/molmil-images/mine/6iej) | The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | Descriptor: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | Authors: | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | Deposit date: | 2018-09-14 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha. Elife, 8, 2019
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4FWR
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![BU of 4fwr by Molmil](/molmil-images/mine/4fwr) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with CMP | Descriptor: | 1,2-ETHANEDIOL, CYTIDINE-5'-MONOPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWM
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![BU of 4fwm by Molmil](/molmil-images/mine/4fwm) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with ATP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWP
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![BU of 4fwp by Molmil](/molmil-images/mine/4fwp) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with GDP | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWL
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![BU of 4fwl by Molmil](/molmil-images/mine/4fwl) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with Phosphate (PO4) | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWN
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![BU of 4fwn by Molmil](/molmil-images/mine/4fwn) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with Adenosine Tetraphosphate (AP4) | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TETRAPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWS
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![BU of 4fws by Molmil](/molmil-images/mine/4fws) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with CTP | Descriptor: | 1,2-ETHANEDIOL, CYTIDINE-5'-TRIPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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4FWK
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![BU of 4fwk by Molmil](/molmil-images/mine/4fwk) | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with AMP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Propionate kinase | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2012-07-01 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies. Biochim.Biophys.Acta, 1834, 2013
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