6WGH

Crystal structure of GDP-bound NRAS with ten residues long internal tandem duplication in the switch II region

Summary for 6WGH

• Entry DOI: 10.2210/pdb6wgh/pdb
• Related: 6PQ3
• Descriptor: GTPase NRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: nras, ras, mg, n-ras, oncoprotein, gdp, internal tandem duplication, itd
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 42282.89

Authors

Dharmaiah, S.,Simanshu, D.K. (deposition date: 2020-04-05, release date: 2020-05-20, Last modification date: 2023-10-18)

• Primary citation: Nelson, A.C.,Turbyville, T.J.,Dharmaiah, S.,Rigby, M.,Yang, R.,Wang, T.Y.,Columbus, J.,Stephens, R.,Taylor, T.,Sciacca, D.,Onsongo, G.,Sarver, A.,Subramanian, S.,Nissley, D.V.,Simanshu, D.K.,Lou, E.; RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.; J.Biol.Chem., 295:9335-9348, 2020; PubMed: 32393580; DOI: 10.1074/jbc.RA119.011080

Experimental method

X-RAY DIFFRACTION (1.65 Å)