6WGH
Crystal structure of GDP-bound NRAS with ten residues long internal tandem duplication in the switch II region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | FLC203 |
| A | HOH326 |
| A | HOH345 |
| A | HOH357 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue GDP A 202 |
| Chain | Residue |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| A | ASN126 |
| A | LYS127 |
| A | ASP129 |
| A | LEU130 |
| A | SER155 |
| A | ALA156 |
| A | LYS157 |
| A | MG205 |
| A | HOH301 |
| A | HOH306 |
| A | HOH311 |
| A | HOH322 |
| A | HOH323 |
| A | HOH327 |
| A | HOH344 |
| A | HOH346 |
| A | HOH358 |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue FLC A 203 |
| Chain | Residue |
| A | HIS27 |
| A | VAL29 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | MG201 |
| A | HOH326 |
| A | HOH345 |
| A | HOH357 |
| B | GLN25 |
| B | ASN26 |
| B | HIS27 |
| B | HOH347 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | ARG83 |
| A | LYS114 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 205 |
| Chain | Residue |
| A | SER17 |
| A | GDP202 |
| A | HOH306 |
| A | HOH311 |
| A | HOH321 |
| A | HOH323 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | SER17 |
| B | GDP202 |
| B | HOH308 |
| B | HOH315 |
| B | HOH316 |
| B | HOH330 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue GDP B 202 |
| Chain | Residue |
| B | GLY13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | VAL29 |
| B | ASP30 |
| B | TYR32 |
| B | ASN126 |
| B | LYS127 |
| B | ASP129 |
| B | SER155 |
| B | ALA156 |
| B | LYS157 |
| B | MG201 |
| B | HOH305 |
| B | HOH308 |
| B | HOH311 |
| B | HOH330 |
| B | HOH338 |
| B | HOH365 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the human NRAS GTPase bound with GDP.","authors":["Nedyalkova L.","Tong Y.","Tempel W.","Shen L.","Loppnau P.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Bochkarev A.","Park H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30712867","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
