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4NH5

Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having 5'-pUU and UU-3' ends (2.55 Angstrom resolution)

Summary for 4NH5
Entry DOI10.2210/pdb4nh5/pdb
Related4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH6 4NHA
DescriptorEndoribonuclease Dicer, 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' (3 entities in total)
Functional Keywordspaz domain, platform domain, connector helix, sirna, rnase iii domain, endoribonuclease, pre-mirna, hydrolase-rna complex, hydrolase/rna
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q9UPY3
Total number of polymer chains2
Total formula weight39329.95
Authors
Tian, Y.,Simanshu, D.K.,Patel, D.J. (deposition date: 2013-11-04, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citationTian, Y.,Simanshu, D.K.,Ma, J.B.,Park, J.E.,Heo, I.,Kim, V.N.,Patel, D.J.
A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Mol.Cell, 53:606-616, 2014
Cited by
PubMed: 24486018
DOI: 10.1016/j.molcel.2014.01.003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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