6MKS
| Cryo-EM structure of NLRC4-CARD filament | Descriptor: | Chimera protein of NLR family CARD domain-containing protein 4 and EGFP | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2018-09-26 | Release date: | 2018-11-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly. J. Biol. Chem., 293, 2018
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6OIF
| Cryo-EM structure of human TorsinA filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Torsin-1A | Authors: | Zheng, W, Demircioglu, F.E, Schwartz, T.U, Egelman, E.H. | Deposit date: | 2019-04-09 | Release date: | 2019-07-24 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn. Nat Commun, 10, 2019
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5W5E
| Re-refinement of the pyocin tube structure | Descriptor: | FIIR2 protein | Authors: | Wang, F, Zheng, W, Taylor, N.M, Guerrero-Ferreira, R.C, Leiman, P.G, Egelman, E.H. | Deposit date: | 2017-06-15 | Release date: | 2017-08-16 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit. Structure, 25, 2017
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3GCB
| GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454 | Descriptor: | GAL6, GLYCEROL, SULFATE ION | Authors: | Joshua-Tor, L, Zheng, W, Johnston, S.A. | Deposit date: | 1998-02-27 | Release date: | 1998-10-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell(Cambridge,Mass.), 93, 1998
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6C53
| Cryo-EM structure of the Type 1 pilus rod | Descriptor: | Type-1 fimbrial protein, A chain | Authors: | Zheng, W, Wang, F, Luna-Rico, A, Francetic, O, Hultgren, S.J, Egelman, E.H. | Deposit date: | 2018-01-13 | Release date: | 2018-01-31 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions. Elife, 7, 2018
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7K3R
| Cryo-EM structure of AIM2-PYD filament | Descriptor: | Interferon-inducible protein AIM2 | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2020-09-12 | Release date: | 2021-05-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat Commun, 12, 2021
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7EIL
| BRD4-BD1 in complex with LT-909-110 | Descriptor: | Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy Eur.J.Med.Chem., 227, 2022
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3L1N
| Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid | Descriptor: | Cell wall antigen, PALMITIC ACID | Authors: | Liao, S, Tung, E.T, Zheng, W, Chong, K, Xu, Y, Bartlam, M, Rao, Z, Yuen, K.Y. | Deposit date: | 2009-12-14 | Release date: | 2010-01-05 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein. J.Biol.Chem., 285, 2010
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4DQM
| Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity | Descriptor: | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha | Authors: | Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. | Deposit date: | 2012-02-16 | Release date: | 2012-10-03 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446, 2012
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4WYB
| Structure of the Bud6 flank domain in complex with actin | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Eck, M.J, Park, E, Zheng, W. | Deposit date: | 2014-11-17 | Release date: | 2015-08-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.493 Å) | Cite: | Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif. Structure, 23, 2015
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6DVR
| Crystal structure of human CARM1 with (R)-SKI-72 | Descriptor: | (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Histone-arginine methyltransferase CARM1, ... | Authors: | Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Luo, M, Cai, X.C, Ke, W, Wang, J, Shi, C, Zheng, W, Lee, J.P, Ibanez, G, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-06-25 | Release date: | 2018-07-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Crystal structure of human CARM1 with (R)-SKI-72 to be published
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5O2Y
| NMR structure of the calcium bound form of PulG, major pseudopilin from Klebsiella oxytoca T2SS | Descriptor: | CALCIUM ION, General secretion pathway protein G | Authors: | Lopez-Castilla, A, Bardiaux, B, Vitorge, B, Thomassin, J.-L, Zheng, W, Yu, X, Egelman, E.H, Nilges, M, Francetic, O, Izadi-Pruneyre, N. | Deposit date: | 2017-05-23 | Release date: | 2017-10-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the calcium-dependent type 2 secretion pseudopilus. Nat Microbiol, 2, 2017
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6GV9
| Structure of the type IV pilus from enterohemorrhagic Escherichia coli (EHEC) | Descriptor: | Prepilin peptidase-dependent protein D | Authors: | Bardiaux, B, Amorim, G.C, Luna-Rico, A, Zheng, W, Guilvout, I, Jollivet, C, Nilges, M, Egelman, E, Francetic, O, Izadi-Pruneyre, N. | Deposit date: | 2018-06-20 | Release date: | 2019-05-15 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus. Structure, 27, 2019
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1CB5
| HUMAN BLEOMYCIN HYDROLASE. | Descriptor: | BLEOMYCIN HYDROLASE | Authors: | O'Farrell, P.A, Gonzalez, F, Zheng, W, Johnston, S.A, Joshua-Tor, L. | Deposit date: | 1999-03-01 | Release date: | 2000-03-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure Fold.Des., 7, 1999
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2CB5
| HUMAN BLEOMYCIN HYDROLASE, C73S/DELE455 MUTANT | Descriptor: | PROTEIN (BLEOMYCIN HYDROLASE) | Authors: | O'Farrell, P.A, Gonzalez, F, Zheng, W, Johnston, S.A, Joshua-Tor, L. | Deposit date: | 1999-03-02 | Release date: | 2000-03-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure Fold.Des., 7, 1999
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6D2L
| Crystal structure of human CARM1 with (S)-SKI-72 | Descriptor: | (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | Authors: | DONG, A, ZENG, H, WALKER, J.R, Hutchinson, A, Seitova, A, LUO, M, CAI, X.C, KE, W, WANG, J, SHI, C, ZHENG, W, LEE, J.P, IBANEZ, G, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2018-04-13 | Release date: | 2018-05-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
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6WQ2
| Cryo-EM of the S. islandicus filamentous virus, SIFV | Descriptor: | A-DNA, Structural protein MCP1, Structural protein MCP2 | Authors: | Wang, F, Baquero, D.P, Su, Z, Zheng, W, Prangishvili, D, Krupovic, M, Egelman, E.H. | Deposit date: | 2020-04-28 | Release date: | 2020-07-29 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. Proc.Natl.Acad.Sci.USA, 117, 2020
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3D4B
| Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ | Descriptor: | 5'-O-[(R)-{[(R)-{[(3R,4R)-1-(3-carbamoylbenzyl)-4-hydroxypyrrolidin-3-yl]methoxy}(hydroxy)phosphoryl]methyl}(hydroxy)phosphoryl]adenosine, Acetyl P53 peptide, NAD-dependent deacetylase, ... | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | Deposit date: | 2008-05-14 | Release date: | 2008-09-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure, 16, 2008
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3D81
| Sir2-S-alkylamidate complex crystal structure | Descriptor: | NAD-dependent deacetylase, S-alkylamidate intermediate, ZINC ION | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | Deposit date: | 2008-05-22 | Release date: | 2008-09-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure, 16, 2008
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5WCO
| Matrix Protein (M1) of Infectious Salmon Anaemia Virus | Descriptor: | NS2 | Authors: | Zhang, W, Zheng, W, Toh, Y, Betancourt, M.A, Tu, J, Fan, Y, Vakharia, V, Liu, J, McNew, J.A, Jin, M, Tao, Y.J. | Deposit date: | 2017-07-01 | Release date: | 2017-08-16 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4IKP
| Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin | Descriptor: | (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | Authors: | Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-27 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
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3RBW
| Crystal structure of Spire KIND domain | Descriptor: | Protein spire homolog 1 | Authors: | Vizcarra, C.L, Kreutz, B, Rodal, A.A, Toms, A.V, Lu, J, Zheng, W, Quinlan, M.E, Eck, M.J. | Deposit date: | 2011-03-30 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins Proc.Natl.Acad.Sci.USA, 2011
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5WDA
| Structure of the PulG pseudopilus | Descriptor: | CALCIUM ION, General secretion pathway protein G | Authors: | Lopez-Castilla, A, Thomassin, J.L, Bardiaux, B, Zheng, W, Nivaskumar, M, Yu, X, Nilges, M, Egelman, E.H, Izadi-Pruneyre, N, Francetic, O. | Deposit date: | 2017-07-04 | Release date: | 2017-10-25 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structure of the calcium-dependent type 2 secretion pseudopilus. Nat Microbiol, 2, 2017
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7VFJ
| Cytochrome c-type biogenesis protein CcmABCD | Descriptor: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | Authors: | Zhu, J.P, Zhang, K, Li, J, Zheng, W, Gu, M. | Deposit date: | 2021-09-13 | Release date: | 2022-11-09 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structures of the CcmABCD heme release complex at multiple states. Nat Commun, 13, 2022
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7VFP
| Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | Authors: | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | Deposit date: | 2021-09-13 | Release date: | 2022-11-09 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Structures of the CcmABCD heme release complex at multiple states. Nat Commun, 13, 2022
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