3D4B
Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+
Summary for 3D4B
Entry DOI | 10.2210/pdb3d4b/pdb |
Descriptor | NAD-dependent deacetylase, Acetyl P53 peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | rossmann fold, cytoplasm, hydrolase, metal-binding, nad, zinc |
Biological source | Thermotoga maritima |
Cellular location | Cytoplasm (Probable): Q9WYW0 |
Total number of polymer chains | 2 |
Total formula weight | 29409.07 |
Authors | Hawse, W.F.,Hoff, K.G.,Fatkins, D.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C. (deposition date: 2008-05-14, release date: 2008-09-30, Last modification date: 2011-07-13) |
Primary citation | Hawse, W.F.,Hoff, K.G.,Fatkins, D.G.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C. Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure, 16:1368-1377, 2008 Cited by PubMed: 18786399DOI: 10.1016/j.str.2008.05.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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