3D4B
Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS148 |
| A | CYS151 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE DZD A 1002 |
| Chain | Residue |
| A | PRO27 |
| A | ILE30 |
| A | PRO31 |
| A | ASP32 |
| A | PHE33 |
| A | GLN98 |
| A | ASN99 |
| A | ILE100 |
| A | ASP101 |
| A | HIS116 |
| A | PHE162 |
| A | GLY188 |
| A | SER189 |
| A | SER190 |
| A | ASN214 |
| A | LEU215 |
| A | GLY216 |
| A | MET230 |
| A | ASP231 |
| A | HOH1003 |
| A | HOH1010 |
| A | HOH1077 |
| A | HOH1114 |
| A | GLY21 |
| A | ALA22 |
| A | GLY23 |
| A | SER25 |
| A | THR26 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18786399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19801667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21080423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PDH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
