Cryo-EM structure of human TorsinA filament

This is a large structure.

Summary for 6OIF

EMDB information20076
DescriptorTorsin-1A, ADENOSINE-5'-TRIPHOSPHATE (2 entities in total)
Functional Keywordsaaa+ atpase, nucleotide binding, nuclear envelope, endoplasmic reticulum, membrane, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains25
Total molecular weight827435.73
Zheng, W.,Demircioglu, F.E.,Schwartz, T.U.,Egelman, E.H. (deposition date: 2019-04-09, release date: 2019-07-24, Last modification date: 2019-08-07)
Primary citation
Demircioglu, F.E.,Zheng, W.,McQuown, A.J.,Maier, N.K.,Watson, N.,Cheeseman, I.M.,Denic, V.,Egelman, E.H.,Schwartz, T.U.
The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn.
Nat Commun, 10:3262-3262, 2019
PubMed: 31332180 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-11194-w
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers60 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures