6D2L

Crystal structure of human CARM1 with (S)-SKI-72

Summary for 6D2L

• Entry DOI: 10.2210/pdb6d2l/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: carm1, prmt4, ski-72 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q86X55
• Total number of polymer chains: 6
• Total formula weight: 237959.30

Authors

DONG, A.,ZENG, H.,WALKER, J.R.,Hutchinson, A.,Seitova, A.,LUO, M.,CAI, X.C.,KE, W.,WANG, J.,SHI, C.,ZHENG, W.,LEE, J.P.,IBANEZ, G.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC) (deposition date: 2018-04-13, release date: 2018-05-23, Last modification date: 2023-08-16)

• Primary citation: Cai, X.C.,Zhang, T.,Kim, E.J.,Jiang, M.,Wang, K.,Wang, J.,Chen, S.,Zhang, N.,Wu, H.,Li, F.,Dela Sena, C.C.,Zeng, H.,Vivcharuk, V.,Niu, X.,Zheng, W.,Lee, J.P.,Chen, Y.,Barsyte, D.,Szewczyk, M.,Hajian, T.,Ibanez, G.,Dong, A.,Dombrovski, L.,Zhang, Z.,Deng, H.,Min, J.,Arrowsmith, C.H.,Mazutis, L.,Shi, L.,Vedadi, M.,Brown, P.J.,Xiang, J.,Qin, L.X.,Xu, W.,Luo, M.; A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.; Elife, 8:-, 2019; PubMed: 31657716; DOI: 10.7554/eLife.47110

Experimental method

X-RAY DIFFRACTION (2 Å)