4NYZ
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![BU of 4nyz by Molmil](/molmil-images/mine/4nyz) | The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution | Descriptor: | GLUTAMINE, GLYCEROL, Genome polyprotein, ... | Authors: | Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N. | Deposit date: | 2013-12-11 | Release date: | 2014-03-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site J.Virol., 88, 2014
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4NZ0
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![BU of 4nz0 by Molmil](/molmil-images/mine/4nz0) | |
7P27
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![BU of 7p27 by Molmil](/molmil-images/mine/7p27) | NMR solution structure of Chikungunya virus macro domain | Descriptor: | Polyprotein P1234 | Authors: | Lykouras, M.V, Tsika, A.C, Papageorgiou, N, Canard, B, Coutard, B, Bentrop, D, Spyroulias, G.A. | Deposit date: | 2021-07-04 | Release date: | 2022-07-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity. J.Mol.Biol., 434, 2022
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3ELD
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![BU of 3eld by Molmil](/molmil-images/mine/3eld) | Wesselsbron methyltransferase in complex with Sinefungin | Descriptor: | Methyltransferase, SINEFUNGIN, SULFATE ION | Authors: | Bollati, M, Milani, M, Mastrangelo, E, Ricagno, S, Bolognesi, M. | Deposit date: | 2008-09-22 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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3ELU
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![BU of 3elu by Molmil](/molmil-images/mine/3elu) | Wesselsbron virus Methyltransferase in complex with AdoMet | Descriptor: | Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION | Authors: | Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2008-09-23 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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3EMD
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![BU of 3emd by Molmil](/molmil-images/mine/3emd) | Wesselsbron virus Methyltransferase in complex with Sinefungin and 7MeGpppA | Descriptor: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, SULFATE ION, ... | Authors: | Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2008-09-24 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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3ELY
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![BU of 3ely by Molmil](/molmil-images/mine/3ely) | Wesselsbron virus Methyltransferase in complex with AdoHcy | Descriptor: | DI(HYDROXYETHYL)ETHER, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2008-09-23 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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3EMB
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![BU of 3emb by Molmil](/molmil-images/mine/3emb) | Wesselsbron virus Methyltransferase in complex with AdoMet and 7MeGpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Methyltransferase, S-ADENOSYLMETHIONINE, ... | Authors: | Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2008-09-24 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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3ELW
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![BU of 3elw by Molmil](/molmil-images/mine/3elw) | Wesselsbron virus Methyltransferase in complex with AdoMet and GpppG | Descriptor: | DIGUANOSINE-5'-TRIPHOSPHATE, Methyltransferase, S-ADENOSYLMETHIONINE, ... | Authors: | Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2008-09-23 | Release date: | 2008-11-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus J.Mol.Biol., 385, 2009
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2WA1
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![BU of 2wa1 by Molmil](/molmil-images/mine/2wa1) | Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV) | Descriptor: | NON-STRUCTURAL PROTEIN 5, SULFATE ION | Authors: | Jansson, A.M, Johansson, P, Jones, T.A. | Deposit date: | 2009-02-02 | Release date: | 2009-08-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Methyltransferase Domain from the Modoc Virus, a Flavivirus with No Known Vector. Acta Crystallogr.,Sect.D, 65, 2009
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2WA2
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![BU of 2wa2 by Molmil](/molmil-images/mine/2wa2) | Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV) | Descriptor: | NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, SULFATE ION | Authors: | Jansson, A.M, Johansson, P, Jones, T.A. | Deposit date: | 2009-02-02 | Release date: | 2009-08-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the Methyltransferase Domain from the Modoc Virus, a Flavivirus with No Known Vector. Acta Crystallogr.,Sect.D, 65, 2009
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5E9Q
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![BU of 5e9q by Molmil](/molmil-images/mine/5e9q) | |
5EIF
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![BU of 5eif by Molmil](/molmil-images/mine/5eif) | |
5EHG
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![BU of 5ehg by Molmil](/molmil-images/mine/5ehg) | |
5EKX
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![BU of 5ekx by Molmil](/molmil-images/mine/5ekx) | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11 | Descriptor: | 4-chloro-5-methylbenzene-1,2-diamine, NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE | Authors: | Barral, K, Bricogne, G, Sharff, A. | Deposit date: | 2015-11-04 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
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5EC8
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![BU of 5ec8 by Molmil](/molmil-images/mine/5ec8) | |
5EHI
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![BU of 5ehi by Molmil](/molmil-images/mine/5ehi) | |
5EIW
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![BU of 5eiw by Molmil](/molmil-images/mine/5eiw) | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2 | Descriptor: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, NS5 methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Barral, K, Bricogne, G, Sharff, A. | Deposit date: | 2015-10-30 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.611 Å) | Cite: | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
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3ZVB
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![BU of 3zvb by Molmil](/molmil-images/mine/3zvb) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 81 | Descriptor: | 3C PROTEASE, ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | Authors: | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | Deposit date: | 2011-07-24 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVC
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![BU of 3zvc by Molmil](/molmil-images/mine/3zvc) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 82 | Descriptor: | 3C PROTEASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | Authors: | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | Deposit date: | 2011-07-24 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVD
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![BU of 3zvd by Molmil](/molmil-images/mine/3zvd) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 83 | Descriptor: | 3C PROTEASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | Authors: | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | Deposit date: | 2011-07-24 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZV8
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![BU of 3zv8 by Molmil](/molmil-images/mine/3zv8) | |
3ZVG
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![BU of 3zvg by Molmil](/molmil-images/mine/3zvg) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 98 | Descriptor: | 3C PROTEASE, N-(tert-butoxycarbonyl)-O-tert-butyl-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide | Authors: | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | Deposit date: | 2011-07-24 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3EW5
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![BU of 3ew5 by Molmil](/molmil-images/mine/3ew5) | Structure of the tetragonal crystal form of X (ADRP) domain from FCoV | Descriptor: | CHLORIDE ION, SN-GLYCEROL-1-PHOSPHATE, SULFATE ION, ... | Authors: | Wojdyla, J.A, Manolaridis, I, Tucker, P.A. | Deposit date: | 2008-10-14 | Release date: | 2009-10-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the X (ADRP) domain of nsp3 from feline coronavirus Acta Crystallogr.,Sect.D, 65, 2009
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3ZVA
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![BU of 3zva by Molmil](/molmil-images/mine/3zva) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 75 | Descriptor: | 3C PROTEASE, ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | Authors: | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | Deposit date: | 2011-07-24 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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