5E9Q
DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174
Summary for 5E9Q
| Entry DOI | 10.2210/pdb5e9q/pdb |
| Descriptor | Genome polyprotein, S-ADENOSYLMETHIONINE, 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid, ... (4 entities in total) |
| Functional Keywords | transferase, dengue virus, ns5 methyltransferase, fragment-based drug discovery |
| Biological source | Dengue virus 3 (DENV-3) |
| Total number of polymer chains | 2 |
| Total formula weight | 59491.51 |
| Authors | Barral, K.,Bricogne, G.,Sharff, A. (deposition date: 2015-10-15, release date: 2016-10-26, Last modification date: 2024-01-10) |
| Primary citation | Benmansour, F.,Trist, I.,Coutard, B.,Decroly, E.,Querat, G.,Brancale, A.,Barral, K. Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125:865-880, 2016 Cited by PubMed: 27750202DOI: 10.1016/j.ejmech.2016.10.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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