3ZVC

3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 82

Summary for 3ZVC

Entry DOI	10.2210/pdb3zvc/pdb
Related	3ZV8 3ZV9 3ZVA 3ZVB 3ZVD 3ZVE 3ZVF 3ZVG
Descriptor	3C PROTEASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE (3 entities in total)
Functional Keywords	hydrolase, michael inhibitor
Biological source	HUMAN ENTEROVIRUS
Total number of polymer chains	1
Total formula weight	21857.83
Authors	Tan, J.,Perbandt, M.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-07-24, release date: 2012-08-08, Last modification date: 2023-12-20)
Primary citation	Tan, J.,George, S.,Kusov, Y.,Perbandt, M.,Anemuller, S.,Mesters, J.R.,Norder, H.,Coutard, B.,Lacroix, C.,Leyssen, P.,Neyts, J.,Hilgenfeld, R. 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87:4339-, 2013 Cited by PubMed: 23388726 DOI: 10.1128/JVI.01123-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation