3ZVF

3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 85

Summary for 3ZVF

Entry DOI	10.2210/pdb3zvf/pdb
Related	3ZV8 3ZV9 3ZVA 3ZVB 3ZVC 3ZVD 3ZVE 3ZVG
Descriptor	3C PROTEASE, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total)
Functional Keywords	hydrolase, michael inhibitor
Biological source	HUMAN ENTEROVIRUS
Total number of polymer chains	1
Total formula weight	21815.80
Authors	Tan, J.,Perbandt, M.,Mesters, J.R.,Hilgenfeld, R. (deposition date: 2011-07-24, release date: 2012-08-08, Last modification date: 2023-12-20)
Primary citation	Tan, J.,George, S.,Kusov, Y.,Perbandt, M.,Anemuller, S.,Mesters, J.R.,Norder, H.,Coutard, B.,Lacroix, C.,Leyssen, P.,Neyts, J.,Hilgenfeld, R. 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87:4339-, 2013 Cited by PubMed: 23388726 DOI: 10.1128/JVI.01123-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation