5EIF

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB2C3

Summary for 5EIF

• Entry DOI: 10.2210/pdb5eif/pdb
• Descriptor: Genome polyprotein, S-ADENOSYLMETHIONINE, 2-azanyl-4-methyl-benzoic acid, ... (4 entities in total)
• Functional Keywords: transferase, dengue virus, ns5 methyltransferase, fragment-based drug discovery
• Biological source: Dengue virus type 3 (DENV-3)
• Cellular location: Protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P27915
• Total number of polymer chains: 2
• Total formula weight: 63361.66

Authors

Barral, K.,Bricogne, G.,Sharff, A. (deposition date: 2015-10-29, release date: 2016-10-26, Last modification date: 2024-01-10)

• Primary citation: Benmansour, F.,Trist, I.,Coutard, B.,Decroly, E.,Querat, G.,Brancale, A.,Barral, K.; Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.; Eur.J.Med.Chem., 125:865-880, 2016; PubMed: 27750202; DOI: 10.1016/j.ejmech.2016.10.007

Experimental method

X-RAY DIFFRACTION (1.5 Å)