6M20
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![BU of 6m20 by Molmil](/molmil-images/mine/6m20) | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | Descriptor: | Hexose transporter 1, beta-D-glucopyranose, nonyl beta-D-glucopyranoside | Authors: | Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N. | Deposit date: | 2020-02-26 | Release date: | 2020-09-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell, 183, 2020
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7CLA
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![BU of 7cla by Molmil](/molmil-images/mine/7cla) | |
1GKO
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![BU of 1gko by Molmil](/molmil-images/mine/1gko) | An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured | Descriptor: | TRANSTHYRETIN | Authors: | Jiang, X, Smith, C.S, Petrassi, H.M, Hammarstrom, P, White, J.T, Sacchettini, J.C, Kelly, J.W. | Deposit date: | 2001-08-17 | Release date: | 2001-11-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Engineered Transthyretin Monomer that is Nonamyloidogenic, Unless It is Partially Denatured Biochemistry, 40, 2001
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3WZF
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![BU of 3wzf by Molmil](/molmil-images/mine/3wzf) | Crystal structure of human cytoplasmic aspartate aminotransferase | Descriptor: | Aspartate aminotransferase, cytoplasmic | Authors: | Jiang, X, Chang, H, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2014-09-24 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.991 Å) | Cite: | Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase To be Published
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1SCF
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![BU of 1scf by Molmil](/molmil-images/mine/1scf) | HUMAN RECOMBINANT STEM CELL FACTOR | Descriptor: | CALCIUM ION, PENTAETHYLENE GLYCOL, STEM CELL FACTOR | Authors: | Jiang, X, Gurel, O, Langley, K.E, Hendrickson, W.A. | Deposit date: | 1998-06-04 | Release date: | 2000-07-07 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the active core of human stem cell factor and analysis of binding to its receptor kit. EMBO J., 19, 2000
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7CB1
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![BU of 7cb1 by Molmil](/molmil-images/mine/7cb1) | Structure of Serratia marcescens chitinase B complexed with compound 6q | Descriptor: | 6-azanyl-11-methyl-2-oxidanylidene-N-[(1S)-1-pyridin-3-ylethyl]-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3,5,7,9,11,13-hexaene-5-carboxamide, Chitinase B | Authors: | Jiang, X, Yuan, P.T. | Deposit date: | 2020-06-10 | Release date: | 2021-06-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Discovery of novel Chitinase Inhibitors with a scaffold of dipyridopyrimidine-3-carboxamide via Structure-based Rational Design To Be Published
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4MQW
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![BU of 4mqw by Molmil](/molmil-images/mine/4mqw) | Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle-stimulating hormone receptor, ... | Authors: | Jiang, X, Liu, H, Chen, X, He, X. | Deposit date: | 2013-09-16 | Release date: | 2014-04-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J.Biol.Chem., 289, 2014
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6IZO
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![BU of 6izo by Molmil](/molmil-images/mine/6izo) | Crystal structure of DNA polymerase sliding clamp from Caulobacter crescentus | Descriptor: | 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER | Authors: | Jiang, X, Zhang, L, Teng, M, Li, X. | Deposit date: | 2018-12-20 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J., 287, 2020
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6JIR
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![BU of 6jir by Molmil](/molmil-images/mine/6jir) | Crystal structure of C. crescentus beta sliding clamp with PEG bound to putative beta-motif tethering region | Descriptor: | 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jiang, X, Teng, M, Li, X. | Deposit date: | 2019-02-23 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J., 287, 2020
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5AX8
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![BU of 5ax8 by Molmil](/molmil-images/mine/5ax8) | Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase | Descriptor: | Aspartate aminotransferase, mitochondrial | Authors: | Jiang, X, Wang, J, Chang, H, Zhou, Y. | Deposit date: | 2015-07-20 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase Biosci Trends, 10, 2016
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4GV9
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![BU of 4gv9 by Molmil](/molmil-images/mine/4gv9) | Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4GV3
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![BU of 4gv3 by Molmil](/molmil-images/mine/4gv3) | Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4GVE
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![BU of 4gve by Molmil](/molmil-images/mine/4gve) | Tacaribe nucleoprotein structure | Descriptor: | MAGNESIUM ION, Nucleoprotein, ZINC ION | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4GV6
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![BU of 4gv6 by Molmil](/molmil-images/mine/4gv6) | Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4G9Z
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![BU of 4g9z by Molmil](/molmil-images/mine/4g9z) | Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression | Descriptor: | Nucleoprotein, RNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2012-07-24 | Release date: | 2013-04-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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6N3I
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![BU of 6n3i by Molmil](/molmil-images/mine/6n3i) | |
6JK6
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![BU of 6jk6 by Molmil](/molmil-images/mine/6jk6) | Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 2-8-s2 | Descriptor: | 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitotriosidase-1 | Authors: | Jiang, X, Yang, Q. | Deposit date: | 2019-02-27 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.571 Å) | Cite: | A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020
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6JMN
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![BU of 6jmn by Molmil](/molmil-images/mine/6jmn) | Crystal structure of Ostrinia furnacalis Chitinase h complexed with compound 2-8-s2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitinase | Authors: | Jiang, X, Yang, Q. | Deposit date: | 2019-03-12 | Release date: | 2020-05-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020
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6JJR
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![BU of 6jjr by Molmil](/molmil-images/mine/6jjr) | Crystal structure of human chitotriosidase-1 (hChit1) catalytic domain in complex with compound 2-8-14 | Descriptor: | 6-azanyl-2-oxidanylidene-N-[(1S)-1-phenylethyl]-7-(phenylmethyl)-1$l^{4},9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaene-5-carboxamide, Chitotriosidase-1 | Authors: | Jiang, X, Yang, Q. | Deposit date: | 2019-02-26 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.834 Å) | Cite: | A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020
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6JK9
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![BU of 6jk9 by Molmil](/molmil-images/mine/6jk9) | Crystal structure of Serratia marcescens Chitinase B complexed with compound 2-8-14 | Descriptor: | 6-azanyl-2-oxidanylidene-N-[(1S)-1-phenylethyl]-7-(phenylmethyl)-1$l^{4},9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaene-5-carboxamide, Chitinase | Authors: | Jiang, X, Yang, Q. | Deposit date: | 2019-02-27 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.312 Å) | Cite: | A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020
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3F8A
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![BU of 3f8a by Molmil](/molmil-images/mine/3f8a) | Crystal Structure of the R132K:R111L:L121E:R59W Mutant of Cellular Retinoic Acid-Binding Protein Type II Complexed with C15-aldehyde (a retinal analog) at 1.95 Angstrom resolution. | Descriptor: | 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular retinoic acid-binding protein 2 | Authors: | Jia, X, Geiger, J.H. | Deposit date: | 2008-11-12 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing Wavelength Regulation with an Engineered Rhodopsin Mimic and a C15-Retinal Analogue Chempluschem, 77, 2012
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2M7Z
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![BU of 2m7z by Molmil](/molmil-images/mine/2m7z) | Structure of SmTSP2EC2 | Descriptor: | CD63-like protein Sm-TSP-2 | Authors: | Mulvenna, J, Jia, X. | Deposit date: | 2013-05-02 | Release date: | 2014-01-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni J.Biol.Chem., 289, 2014
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6URI
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![BU of 6uri by Molmil](/molmil-images/mine/6uri) | |
3I17
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3FEP
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![BU of 3fep by Molmil](/molmil-images/mine/3fep) | Crystal structure of the R132K:R111L:L121E:R59W-CRABPII mutant complexed with a synthetic ligand (merocyanin) at 2.60 angstrom resolution. | Descriptor: | (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular retinoic acid-binding protein 2 | Authors: | Jia, X, Geiger, J.H. | Deposit date: | 2008-11-30 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | "Turn-on" protein fluorescence: in situ formation of cyanine dyes. J.Am.Chem.Soc., 137, 2015
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