4GV9

Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min

Summary for 4GV9

Related3MWP 4GV6 4GV3
DescriptorRNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ... (6 entities in total)
Functional Keywordsdeddh family enzyme, 3'-5' exonuclease, dsrna, rna binding protein-rna complex, rna binding protein/rna
Biological sourceLassa virus (LASV)
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Cellular locationVirion P13699
Total number of polymer chains3
Total molecular weight27220.63
Authors
Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C. (deposition date: 2012-08-30, release date: 2013-05-01, Last modification date: 2013-07-10)
Primary citation
Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C.
Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288:16949-16959, 2013
PubMed: 23615902 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.420521
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.46 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.30741.0%1.7%5.8%0.53MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4gv9
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Molmil generated image of 4gv9
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Molmil generated image of 4gv9
rotated about y axis by 90°