4G9Z

Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression

Summary for 4G9Z

Related3MWP 3MX5 3MX2 3MWT
DescriptorRNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), Nucleoprotein, ... (5 entities in total)
Functional Keywordsstructural genomics, scottish structural proteomics facility, sspf, 3'-5'-ribonuclease, nuclease, viral protein-rna complex, viral protein/rna
Biological sourceLassa virus
Cellular locationVirion P13699
Total number of polymer chains3
Total molecular weight26590.67
Authors
Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C.,Scottish Structural Proteomics Facility (SSPF) (deposition date: 2012-07-24, release date: 2013-04-03, Last modification date: 2013-07-24)
Primary citation
Jiang, X.,Huang, Q.,Wang, W.,Dong, H.,Ly, H.,Liang, Y.,Dong, C.
Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288:16949-16959, 2013
PubMed: 23615902 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.420521
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.03 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.249101.1%2.3%0.70MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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