5NQ5
| Mtb TMK crystal structure in complex with compound 1 | Descriptor: | 5-methyl-1-[(3~{S})-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4-dione, Thymidylate kinase | Authors: | Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S. | Deposit date: | 2017-04-19 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J. Med. Chem., 61, 2018
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5O2P
| p130Cas SH3 domain PTP-PEST peptide chimera | Descriptor: | Breast cancer anti-estrogen resistance 1,Tyrosine-protein phosphatase non-receptor type 12 | Authors: | Hexnerova, R, Veverka, V. | Deposit date: | 2017-05-22 | Release date: | 2017-09-20 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
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8CR6
| mouse Interleukin-12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit alpha, Interleukin-12 subunit beta, ... | Authors: | Merceron, R, Felix, J, Lambert, E, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-07 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8CR5
| Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, Interleukin-12 subunit beta, ... | Authors: | Merceron, R, Bloch, Y, Felix, J, Savvides, S.N. | Deposit date: | 2023-03-07 | Release date: | 2024-02-07 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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6YT1
| Mtb TMK crystal structure in complex with compound 26 | Descriptor: | 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase | Authors: | Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N. | Deposit date: | 2020-04-23 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur.J.Med.Chem., 206, 2020
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6GFF
| Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ... | Authors: | Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S. | Deposit date: | 2018-04-30 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells. Science, 362, 2018
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7TZD
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7TZ8
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2MVC
| Solution structure of human insulin at pH 1.9 | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. | Deposit date: | 2014-10-02 | Release date: | 2014-12-10 | Last modified: | 2016-06-01 | Method: | SOLUTION NMR | Cite: | Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young. Plos One, 9, 2014
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2MVD
| Solution structure of [GlnB22]-insulin mutant at pH 1.9 | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Hexnerova, R, Krizkova, K, Maletinska, L, Jiracek, J, Brzozowski, A.M, Zakova, L, Veverka, V. | Deposit date: | 2014-10-02 | Release date: | 2014-12-10 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural and Functional Study of the GlnB22-Insulin Mutant Responsible for Maturity-Onset Diabetes of the Young. Plos One, 9, 2014
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4V90
| Thermus thermophilus Ribosome | Descriptor: | 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Chen, Y, Feng, S, Kumar, V, Ero, R, Gao, Y.G. | Deposit date: | 2014-02-22 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of EF-G-ribosome complex in a pretranslocation state. Nat. Struct. Mol. Biol., 20, 2013
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5ZLU
| Ribosome Structure bound to ABC-F protein. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Su, W.X, Kumar, V, Ero, R, Andrew, S.W.W, Jian, S, Yong-Gui, G. | Deposit date: | 2018-03-29 | Release date: | 2018-08-01 | Last modified: | 2019-12-04 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Ribosome protection by antibiotic resistance ATP-binding cassette protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6IUY
| Structure of DsGPDH of Dunaliella salina | Descriptor: | 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL, Glycerol-3-phosphate dehydrogenase [NAD(+)], ... | Authors: | He, Q, Toh, J.D, Ero, R, Qiao, Z, Kumar, V, Gao, Y.G. | Deposit date: | 2018-12-01 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol. Plant J., 102, 2020
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5IMQ
| Structure of ribosome bound to cofactor at 3.8 angstrom resolution | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Kumar, V, Ero, R, Jian, G.K, Ahmed, T, Zhan, Y, Bhushan, S, Gao, Y.G. | Deposit date: | 2016-03-06 | Release date: | 2016-05-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome J.Biol.Chem., 291, 2016
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5IMR
| Structure of ribosome bound to cofactor at 5.7 angstrom resolution | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Kumar, V, Ero, R, Jian, G.K, Ahmed, T, Zhan, Y, Bhushan, S, Gao, Y.G. | Deposit date: | 2016-03-06 | Release date: | 2016-05-18 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome J.Biol.Chem., 291, 2016
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7C3M
| Structure of FERM protein | Descriptor: | Fermitin family homolog 3,Fermitin family homolog 3,Fermitin family homolog 3 | Authors: | Bu, W, Loh, Z.Y, Jin, S, Basu, S, Ero, R, Park, J.E, Yan, X, Wang, M, Sze, S.K, Tan, S.M, Gao, Y.G. | Deposit date: | 2020-05-13 | Release date: | 2020-06-03 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. Plos Biol., 18, 2020
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5A9Y
| Structure of ppGpp BipA | Descriptor: | GTP-BINDING PROTEIN, GUANOSINE-5',3'-TETRAPHOSPHATE | Authors: | Kumar, V, Chen, Y, Ero, R, Li, Z, Gao, Y.-G. | Deposit date: | 2015-07-23 | Release date: | 2015-08-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5A9X
| Structure of GDP bound BipA | Descriptor: | GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE | Authors: | Kumar, V, Chen, Y, Ero, R, Li, Z, Gao, Y.-G. | Deposit date: | 2015-07-23 | Release date: | 2015-08-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5A9W
| Structure of GDPCP BipA | Descriptor: | GTP-BINDING PROTEIN, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Kumar, V, Chen, Y, Ero, R, Li, Z, Gao, Y. | Deposit date: | 2015-07-23 | Release date: | 2015-08-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5A9V
| Structure of apo BipA | Descriptor: | GTP-BINDING PROTEIN | Authors: | Kumar, V, Chen, Y, Ero, R, Li, Z, Gao, Y. | Deposit date: | 2015-07-23 | Release date: | 2015-09-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5A9Z
| Complex of Thermous thermophilus ribosome bound to BipA-GDPCP | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Kumar, V, Chen, Y, Ahmed, T, Tan, J, Ero, R, Bhushan, S, Gao, Y.-G. | Deposit date: | 2015-07-23 | Release date: | 2015-10-14 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5AA0
| Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... | Authors: | Kumar, V, Chen, Y, Ahmed, T, Tan, J, Ero, R, Bhushan, S, Gao, Y.-G. | Deposit date: | 2015-07-23 | Release date: | 2015-10-14 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structure of Bipa in GTP Form Bound to the Ratcheted Ribosome. Proc.Natl.Acad.Sci.USA, 112, 2015
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3MEF
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2UY5
| ScCTS1_kinetin crystal structure | Descriptor: | ENDOCHITINASE, N-(FURAN-2-YLMETHYL)-7H-PURIN-6-AMINE | Authors: | Hurtado-Guerrero, R, van Aalten, D.M.F. | Deposit date: | 2007-04-02 | Release date: | 2007-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Saccharomyces Cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors. Chem.Biol., 14, 2007
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2SPZ
| STAPHYLOCOCCAL PROTEIN A, Z-DOMAIN, NMR, 10 STRUCTURES | Descriptor: | IMMUNOGLOBULIN G BINDING PROTEIN A | Authors: | Montelione, G.T, Tashiro, M, Tejero, R, Lyons, B.A. | Deposit date: | 1998-07-29 | Release date: | 1998-08-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | High-resolution solution NMR structure of the Z domain of staphylococcal protein A. J.Mol.Biol., 272, 1997
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