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5UHD
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BU of 5uhd by Molmil
Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 4nt RNA in complex with Rifampin
Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lin, W, Das, K, Feng, Y, Ebright, R.H.
Deposit date:2017-01-11
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.01 Å)
Cite:Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol. Cell, 66, 2017
5UHC
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BU of 5uhc by Molmil
Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3nt RNA in complex with Rifampin
Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lin, W, Das, K, Feng, Y, Ebright, R.H.
Deposit date:2017-01-11
Release date:2017-04-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.796 Å)
Cite:Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol. Cell, 66, 2017
5UHA
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BU of 5uha by Molmil
Crystal structure of Mycobacterium tuberculosis transcription initiation complex
Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lin, W, Das, K, Feng, Y, Ebright, R.H.
Deposit date:2017-01-11
Release date:2017-04-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.906 Å)
Cite:Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol. Cell, 66, 2017
5UHF
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BU of 5uhf by Molmil
Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-IX336
Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lin, W, Das, K, Feng, Y, Ebright, R.H.
Deposit date:2017-01-11
Release date:2017-04-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.345 Å)
Cite:Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol. Cell, 66, 2017
5UHB
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BU of 5uhb by Molmil
Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with Rifampin
Descriptor: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lin, W, Das, K, Feng, Y, Ebright, R.H.
Deposit date:2017-01-11
Release date:2017-04-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.29 Å)
Cite:Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol. Cell, 66, 2017
6MBK
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BU of 6mbk by Molmil
SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First P212121 Crystal Form
Descriptor: 1,2-ETHANEDIOL, Actin peptide, GLYCEROL, ...
Authors:Horton, J.R, Dai, S, Cheng, X.
Deposit date:2018-08-30
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Nature, 565, 2019
6MBL
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BU of 6mbl by Molmil
SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second P212121 Crystal Form
Descriptor: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ...
Authors:Horton, J.R, Dai, S, Cheng, X.
Deposit date:2018-08-30
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Nature, 565, 2019
7SL6
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BU of 7sl6 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL7
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BU of 7sl7 by Molmil
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R)
Descriptor: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ...
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL2
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BU of 7sl2 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL3
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BU of 7sl3 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL4
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BU of 7sl4 by Molmil
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7SL1
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BU of 7sl1 by Molmil
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor
Authors:Bai, X.C, Choi, E.
Deposit date:2021-10-22
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Synergistic activation of the insulin receptor via two distinct sites.
Nat.Struct.Mol.Biol., 29, 2022
7JVM
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BU of 7jvm by Molmil
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155
Descriptor: (3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11
Authors:Fodor, M, Stams, T.
Deposit date:2020-08-21
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
Descriptor: Bromodomain-containing protein 4, FOXO3a peptide
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
7UF8
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BU of 7uf8 by Molmil
Structure of CtdP in complex with penicimutamide E and NADP+
Descriptor: 1,2-ETHANEDIOL, CtdP, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Rivera, S, Liu, Z, Newmister, S.A, Gao, X, Sherman, D.H.
Deposit date:2022-03-22
Release date:2023-02-22
Last modified:2023-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An NmrA-like enzyme-catalysed redox-mediated Diels-Alder cycloaddition with anti-selectivity.
Nat.Chem., 15, 2023
8IDN
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BU of 8idn by Molmil
Cryo-EM structure of RBD/E77-Fab complex
Descriptor: E77 Fab heavy chain, E77 Fab light chain, Spike protein S1, ...
Authors:Lu, D.F, Zhang, Z.C.
Deposit date:2023-02-13
Release date:2023-06-21
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2.
Acta Crystallogr D Struct Biol, 79, 2023
8EX1
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BU of 8ex1 by Molmil
Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with Reversine
Descriptor: GLYCEROL, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, Tyrosine-protein kinase JAK2
Authors:Sampathkumar, P, Hubbard, S.R.
Deposit date:2022-10-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX0
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BU of 8ex0 by Molmil
Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV
Descriptor: 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2
Authors:Sampathkumar, P, Hubbard, S.R.
Deposit date:2022-10-24
Release date:2023-02-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
8EX2
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BU of 8ex2 by Molmil
Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with HTSA3
Descriptor: 3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,5-a]pyrimidin-7-one, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:Sampathkumar, P, Hubbard, S.R.
Deposit date:2022-10-24
Release date:2023-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Pharmaceuticals, 16, 2023
7E3O
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BU of 7e3o by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody nCoV617
Descriptor: Spike protein S1, nCoV617 Heigh Chain, nCoV617 Light Chain
Authors:Chen, S.D, Yang, M.
Deposit date:2021-02-09
Release date:2021-09-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.
Microbiol Spectr, 9, 2021
1F8Q
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BU of 1f8q by Molmil
CRYSTAL STRUCTURE OF ALPHA-MOMORCHARIN IN ACETONITRILE-WATER MIXTURE
Descriptor: ACETONITRILE, ALPHA-MOMORCHARIN, PENTANEDIAL, ...
Authors:Zhu, G, Huang, Q, Qian, M, Tang, Y.
Deposit date:2000-07-03
Release date:2000-07-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of alpha-momorcharin in 80% acetonitrile--water mixture
BIOCHIM.BIOPHYS.ACTA, 1548, 2001
1G9I
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BU of 1g9i by Molmil
CRYSTAL STRUCTURE OF BETA-TRYSIN COMPLEX IN CYCLOHEXANE
Descriptor: BOWMAN-BIRK TYPE TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ...
Authors:Zhu, G, Huang, Q, Zhu, Y, Li, Y, Chi, C, Tang, Y.
Deposit date:2000-11-24
Release date:2000-12-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-Ray study on an artificial mung bean inhibitor complex with bovine beta-trypsin in neat cyclohexane.
Biochim.Biophys.Acta, 1546, 2001
7CFS
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BU of 7cfs by Molmil
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHOLESTEROL HEMISUCCINATE, ...
Authors:Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L.
Deposit date:2020-06-28
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020
7CFT
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BU of 7cft by Molmil
Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Mambalgin-1
Authors:Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L.
Deposit date:2020-06-28
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020

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PDB entries from 2024-07-17

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