8EX0

Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV

Summary for 8EX0

Entry DOI	10.2210/pdb8ex0/pdb
Descriptor	Tyrosine-protein kinase JAK2, 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide (3 entities in total)
Functional Keywords	janus tyrosine kinase, jak2, pseudokinase, phosphorylation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	33543.48
Authors	Sampathkumar, P.,Hubbard, S.R. (deposition date: 2022-10-24, release date: 2023-02-01, Last modification date: 2024-05-22)
Primary citation	Virtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 36678572 DOI: 10.3390/ph16010075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation