6TGB
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![BU of 6tgb by Molmil](/molmil-images/mine/6tgb) | CryoEM structure of the binary DOCK2-ELMO1 complex | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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6TGC
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![BU of 6tgc by Molmil](/molmil-images/mine/6tgc) | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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7QE7
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![BU of 7qe7 by Molmil](/molmil-images/mine/7qe7) | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2021-12-01 | Release date: | 2022-01-26 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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6QLE
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![BU of 6qle by Molmil](/molmil-images/mine/6qle) | Structure of inner kinetochore CCAN complex | Descriptor: | Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3,Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3, Central kinetochore subunit MCM16,Central kinetochore subunit MCM16,Inner kinetochore subunit MCM16,Mcm16p, Inner kinetochore subunit AME1,Inner kinetochore subunit AME1,Inner kinetochore subunit AME1,Inner kinetochore subunit AME1, ... | Authors: | Yan, K, Yang, J, Zhang, Z, McLaughlin, S.H, Chang, L, Fasci, D, Heck, A.J.R, Barford, D. | Deposit date: | 2019-01-31 | Release date: | 2019-10-02 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome. Nature, 574, 2019
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6QLD
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![BU of 6qld by Molmil](/molmil-images/mine/6qld) | Structure of inner kinetochore CCAN-Cenp-A complex | Descriptor: | DNA (125-MER), Histone H2A.1, Histone H2B.1, ... | Authors: | Yan, K, Yang, J, Zhang, Z, McLaughlin, S.H, Chang, L, Fasci, D, Heck, A.J.R, Barford, D. | Deposit date: | 2019-01-31 | Release date: | 2019-10-02 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.15 Å) | Cite: | Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome. Nature, 574, 2019
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6QLF
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![BU of 6qlf by Molmil](/molmil-images/mine/6qlf) | Structure of inner kinetochore CCAN complex with mask1 | Descriptor: | Inner kinetochore subunit AME1, Inner kinetochore subunit CHL4, Inner kinetochore subunit CTF19, ... | Authors: | Yan, K, Yang, J, Zhang, Z, McLaughlin, S.H, Chang, L, Fasci, D, Heck, A.J.R, Barford, D. | Deposit date: | 2019-01-31 | Release date: | 2019-10-02 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome. Nature, 574, 2019
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8S4G
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![BU of 8s4g by Molmil](/molmil-images/mine/8s4g) | Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2024-02-21 | Release date: | 2024-03-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex To Be Published
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6M4Q
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![BU of 6m4q by Molmil](/molmil-images/mine/6m4q) | Cytochrome P450 monooxygenase StvP2 substrate-free structure | Descriptor: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | Deposit date: | 2020-03-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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6M4P
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![BU of 6m4p by Molmil](/molmil-images/mine/6m4p) | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | Descriptor: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | Deposit date: | 2020-03-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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8XV2
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![BU of 8xv2 by Molmil](/molmil-images/mine/8xv2) | Thiamine-bound human SLC19A3 | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Soluble cytochrome b562,Thiamine transporter 2 | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | Deposit date: | 2024-01-14 | Release date: | 2024-03-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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8XV5
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![BU of 8xv5 by Molmil](/molmil-images/mine/8xv5) | Pyridoxamine-bound human SLC19A3 | Descriptor: | 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL, Soluble cytochrome b562,Thiamine transporter 2 | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | Deposit date: | 2024-01-14 | Release date: | 2024-03-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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5G04
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![BU of 5g04 by Molmil](/molmil-images/mine/5g04) | Structure of the human APC-Cdc20-Hsl1 complex | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | Authors: | Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. | Deposit date: | 2016-03-16 | Release date: | 2016-05-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
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5G05
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![BU of 5g05 by Molmil](/molmil-images/mine/5g05) | Cryo-EM structure of combined apo phosphorylated APC | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | Authors: | Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. | Deposit date: | 2016-03-16 | Release date: | 2016-05-25 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
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5A31
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![BU of 5a31 by Molmil](/molmil-images/mine/5a31) | Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | Authors: | Chang, L, Zhang, Z, Yang, J, Mclaughlin, S.H, Barford, D. | Deposit date: | 2015-05-26 | Release date: | 2015-11-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination. Nature, 522, 2015
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8PKP
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![BU of 8pkp by Molmil](/molmil-images/mine/8pkp) | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2023-06-27 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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7AAP
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![BU of 7aap by Molmil](/molmil-images/mine/7aap) | Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP | Descriptor: | MAGNESIUM ION, Non-structural protein 12, Non-structural protein 7, ... | Authors: | Naydenova, K, Muir, K.W, Wu, L.F, Zhang, Z, Coscia, F, Peet, M, Castro-Hartman, P, Qian, P, Sader, K, Dent, K, Kimanius, D, Sutherland, J.D, Lowe, J, Barford, D, Russo, C.J. | Deposit date: | 2020-09-04 | Release date: | 2020-09-23 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP. Proc.Natl.Acad.Sci.USA, 118, 2021
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7O5N
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![BU of 7o5n by Molmil](/molmil-images/mine/7o5n) | Crystal Structure of a Class D carbapenemase complexed with Avibactam | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1-BUTANOL, Beta-lactamase, ... | Authors: | Zhou, Q, Zhang, Z, He, Y, Jin, Y. | Deposit date: | 2021-04-09 | Release date: | 2022-04-20 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci., 2023
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5BPT
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![BU of 5bpt by Molmil](/molmil-images/mine/5bpt) | |
5BPW
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![BU of 5bpw by Molmil](/molmil-images/mine/5bpw) | |
5BPZ
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![BU of 5bpz by Molmil](/molmil-images/mine/5bpz) | Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain | Descriptor: | 1,2-ETHANEDIOL, Anapc5 protein | Authors: | Cronin, N, Yang, J, Zhang, Z, Barford, D. | Deposit date: | 2015-05-28 | Release date: | 2015-09-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain. J.Mol.Biol., 427, 2015
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7ON1
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![BU of 7on1 by Molmil](/molmil-images/mine/7on1) | Cenp-A nucleosome in complex with Cenp-C | Descriptor: | BJ4_G0006610.mRNA.1.CDS.1, BJ4_G0007000.mRNA.1.CDS.1, DNA (123-MER), ... | Authors: | Yan, K, Yang, J, Zhang, Z, Barford, D. | Deposit date: | 2021-05-25 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cenp-A nucleosome in complex with Cenp-C To Be Published
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5N7Z
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![BU of 5n7z by Molmil](/molmil-images/mine/5n7z) | |
6GYU
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![BU of 6gyu by Molmil](/molmil-images/mine/6gyu) | Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore | Descriptor: | Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-02 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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6GYS
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![BU of 6gys by Molmil](/molmil-images/mine/6gys) | Cryo-EM structure of the CBF3-CEN3 complex of the budding yeast kinetochore | Descriptor: | Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-01 | Release date: | 2018-12-05 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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6GYP
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![BU of 6gyp by Molmil](/molmil-images/mine/6gyp) | Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore | Descriptor: | ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... | Authors: | Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | Deposit date: | 2018-07-01 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
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