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6D8E
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BU of 6d8e by Molmil
Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor
Descriptor: (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate, Epidermal growth factor receptor
Authors:Park, E, Eck, M.J.
Deposit date:2018-04-26
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.537 Å)
Cite:Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Angew. Chem. Int. Ed. Engl., 57, 2018
6AH7
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BU of 6ah7 by Molmil
D45W/H226G mutant of marine bacterial prolidase
Descriptor: MANGANESE (II) ION, SODIUM ION, SULFATE ION, ...
Authors:Jian, Y, Yunzhu, X, Lijuan, L.
Deposit date:2018-08-17
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Repurposing a bacterial prolidase for organophosphorus hydrolysis: Reshaped catalytic cavity switches substrate selectivity.
Biotechnol.Bioeng., 117, 2020
2LVM
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BU of 2lvm by Molmil
Solution structure of human 53BP1 tandem Tudor domains in complex with a histone H4K20me2 peptide
Descriptor: Histone H4, Tumor suppressor p53-binding protein 1
Authors:Cui, G, Botuyan, M, Mer, G.
Deposit date:2012-07-07
Release date:2012-12-12
Last modified:2013-04-03
Method:SOLUTION NMR
Cite:Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
Nat.Struct.Mol.Biol., 20, 2013
3CCP
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BU of 3ccp by Molmil
X-RAY STRUCTURES OF RECOMBINANT YEAST CYTOCHROME C PEROXIDASE AND THREE HEME-CLEFT MUTANTS PREPARED BY SITE-DIRECTED MUTAGENESIS
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, YEAST CYTOCHROME C PEROXIDASE
Authors:Wang, J, Mauro, J.M, Edwards, S.L, Oatley, S.J, Fishel, L.A, Ashford, V.A, Xuong, N.-H, Kraut, J.
Deposit date:1990-02-28
Release date:1991-07-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of recombinant yeast cytochrome c peroxidase and three heme-cleft mutants prepared by site-directed mutagenesis.
Biochemistry, 29, 1990
6AH8
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BU of 6ah8 by Molmil
Marine bacterial prolidase with promiscuous organophosphorus hydrolase activity
Descriptor: MANGANESE (II) ION, SULFATE ION, Xaa-Pro dipeptidase
Authors:Jian, Y.
Deposit date:2018-08-17
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Repurposing a bacterial prolidase for organophosphorus hydrolysis: Reshaped catalytic cavity switches substrate selectivity.
Biotechnol.Bioeng., 117, 2020
2XVO
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BU of 2xvo by Molmil
SSO1725, a protein involved in the CRISPR/Cas pathway
Descriptor: BETA-MERCAPTOETHANOL, SSO1725, SULFATE ION
Authors:Reeks, J, Liu, H, Naismith, J, White, M, McMahon, S.
Deposit date:2010-10-26
Release date:2010-12-29
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure and Mechanism of the Cmr Complex for Crispr-Mediated Antiviral Immunity.
Mol.Cell, 45, 2012
7WZX
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BU of 7wzx by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: (2~{S},4~{S},6~{R})-2-[(2~{S},3~{R},5~{S},6~{R})-3,5-bis(methylamino)-2,4,6-tris(oxidanyl)cyclohexyl]oxy-6-methyl-4-oxidanyl-oxan-3-one, 4Fe-4S cluster-binding domain-containing protein, GLYCEROL, ...
Authors:Hou, X.L, Zhou, J.H.
Deposit date:2022-02-19
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.980013 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
7WZV
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BU of 7wzv by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ...
Authors:Zhou, J.H, Hou, X.L.
Deposit date:2022-02-19
Release date:2022-12-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.899313 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
7X0B
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BU of 7x0b by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: 4Fe-4S cluster-binding domain-containing protein, CHLORIDE ION, GLYCEROL, ...
Authors:Hou, X.L, Zhou, J.H.
Deposit date:2022-02-21
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.02027535 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
6L08
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BU of 6l08 by Molmil
Crystal structure of Arabidopsis cytidine deaminase
Descriptor: Cytidine deaminase 1, SULFATE ION
Authors:Jia, W, Xiao, W, Lin, L.
Deposit date:2019-09-26
Release date:2020-08-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Crystal structure of Arabidopsis thaliana cytidine deaminase.
Biochem.Biophys.Res.Commun., 529, 2020
4ZHK
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BU of 4zhk by Molmil
Crystal structure of RPE65 in complex with MB-002
Descriptor: (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ...
Authors:Kiser, P.D, Palczewski, K.
Deposit date:2015-04-25
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
7D9M
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BU of 7d9m by Molmil
grass carp interleukin-2
Descriptor: Interleukin
Authors:Junya, w, Jun, z.
Deposit date:2020-10-13
Release date:2020-10-28
Last modified:2020-11-11
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural insights into the co-evolution of IL-2 and its private receptor in fish.
Dev.Comp.Immunol., 115, 2020
3ILQ
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BU of 3ilq by Molmil
Structure of mCD1d with bound glycolipid BbGL-2c from Borrelia burgdorferi
Descriptor: (2S)-3-(alpha-D-galactopyranosyloxy)-2-(hexadecanoyloxy)propyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zajonc, D.M.
Deposit date:2009-08-07
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
3ILP
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BU of 3ilp by Molmil
Structure of mCD1d with bound glycolipid BbGL-2f from Borrelia burgdorferi
Descriptor: (2S)-3-(alpha-D-galactopyranosyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z,12Z)-octadeca-9,12-dienoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zajonc, D.M.
Deposit date:2009-08-07
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
7WNW
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BU of 7wnw by Molmil
Crystal structure of Imine Reductase Mutant(M5) from Actinoalloteichus hymeniacidonis in complex with NADPH
Descriptor: 3-hydroxyisobutyrate dehydrogenase-like beta-hydroxyacid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhand, J, Chen, R, Gao, S.
Deposit date:2022-01-19
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering.
Angew.Chem.Int.Ed.Engl., 61, 2022
5ITP
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BU of 5itp by Molmil
Structure of the periplasmic binding protein NocT from A.tumefaciens in complex with octopine
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Nopaline-binding periplasmic protein, ...
Authors:Vigouroux, A, Morera, S.
Deposit date:2016-03-17
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fitness costs restrict niche expansion by generalist niche-constructing pathogens.
ISME J, 11, 2017
5ITO
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BU of 5ito by Molmil
Structure of the periplasmic binding protein M117N-NocT from A. tumefaciens in complex with octopine
Descriptor: 1,2-ETHANEDIOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, DI(HYDROXYETHYL)ETHER, ...
Authors:Vigouroux, A, Morera, S.
Deposit date:2016-03-17
Release date:2016-11-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fitness costs restrict niche expansion by generalist niche-constructing pathogens.
ISME J, 11, 2017
5DFM
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BU of 5dfm by Molmil
Structure of Tetrahymena telomerase p19 fused to MBP
Descriptor: GLYCEROL, Maltose-binding periplasmic protein,Telomerase-associated protein 19, SULFATE ION, ...
Authors:Chan, H, Cascio, D, Sawaya, M.R, Feigon, J.
Deposit date:2015-08-27
Release date:2015-10-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Science, 350, 2015
4NSO
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BU of 4nso by Molmil
Crystal structure of the effector-immunity protein complex
Descriptor: Effector protein, Immunity protein
Authors:Dong, C.
Deposit date:2013-11-28
Release date:2014-04-16
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein.
Febs Lett., 588, 2014
5DFN
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BU of 5dfn by Molmil
Structure of Tetrahymena Telomerase P45 C-terminal domain
Descriptor: Telomerase associated protein p45
Authors:Chan, H, Cascio, D, Sawaya, M.R, Feigon, J.
Deposit date:2015-08-27
Release date:2015-10-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Science, 350, 2015
3Q6S
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BU of 3q6s by Molmil
The crystal structure of the heterochromatin protein 1 beta chromoshadow domain complexed with a peptide from Shugoshin 1
Descriptor: Chromobox protein homolog 1, Shugoshin-like 1
Authors:Brautigam, C.A, Chaudhary, J, Yu, H.
Deposit date:2011-01-03
Release date:2011-12-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
Mol Biol Cell, 22, 2011
4FBZ
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BU of 4fbz by Molmil
Crystal structure of deltarhodopsin from Haloterrigena thermotolerans
Descriptor: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, 2,3-DI-PHYTANYL-GLYCEROL, BACTERIORUBERIN, ...
Authors:Kouyama, T.
Deposit date:2012-05-23
Release date:2013-05-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of deltarhodopsin-3 from Haloterrigena thermotolerans
Proteins, 81, 2013
6LVP
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BU of 6lvp by Molmil
Enoyl-CoA hydratase (HyECH) from Hymenobacter sp. PAMC 26628
Descriptor: Enoyl-CoA hydratase
Authors:Hwang, J.S, Jung, C, Lee, C.W, Lee, J.H.
Deposit date:2020-02-04
Release date:2020-04-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural and sequence comparisons of bacterial enoyl-CoA isomerase and enoyl-CoA hydratase.
J.Microbiol, 58, 2020
4NSR
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BU of 4nsr by Molmil
Crystal structure of the Immunity protein
Descriptor: Immunity protein
Authors:Dong, C, Gao, Z.-Q, Dong, Y.-H.
Deposit date:2013-11-28
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.795 Å)
Cite:Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein.
Febs Lett., 588, 2014
4ZRU
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BU of 4zru by Molmil
X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) in complex with 3-[2-[(2S)-pyrrolidin-2-yl]ethynyl]pyridine (TI-5180)
Descriptor: 3-[(2S)-pyrrolidin-2-ylethynyl]pyridine, Acetylcholine-binding protein, PHOSPHATE ION
Authors:Bobango, J, Sankaran, B, Park, J.F, Wu, J, Talley, T.T.
Deposit date:2015-05-12
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs, and Structural Features of a High-Affinity, Non-selective NNR Ligand-AChBP Co-crystal Structure
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PDB entries from 2024-09-11

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