2OM9
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![BU of 2om9 by Molmil](/molmil-images/mine/2om9) | Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma | Descriptor: | (6AR,10AR)-3-(1,1-DIMETHYLHEPTYL)-1-HYDROXY-6,6-DIMETHYL-6A,7,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMENE-9-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma | Authors: | Ambrosio, A.L.B, Garratt, R.C. | Deposit date: | 2007-01-21 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor gamma J.Biol.Chem., 282, 2007
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1S8H
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![BU of 1s8h by Molmil](/molmil-images/mine/1s8h) | Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, first fatty acid free form | Descriptor: | Phospholipase A2 homolog, SULFATE ION | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
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1S8G
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![BU of 1s8g by Molmil](/molmil-images/mine/1s8g) | Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, fatty acid bound form | Descriptor: | GLYCEROL, LAURIC ACID, Phospholipase A2 homolog, ... | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
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1S8I
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![BU of 1s8i by Molmil](/molmil-images/mine/1s8i) | Crystal structure of Lys49-Phospholipase A2 from Agkistrodon contortrix laticinctus, second fatty acid free form | Descriptor: | Phospholipase A2 homolog, SULFATE ION | Authors: | Ambrosio, A.L.B, de Souza, D.H.F, Nonato, M.C, Selistre de Araujo, H.S, Ownby, C.L, Garratt, R.C. | Deposit date: | 2004-02-02 | Release date: | 2004-02-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.609 Å) | Cite: | A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change. J.Biol.Chem., 280, 2005
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5F28
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![BU of 5f28 by Molmil](/molmil-images/mine/5f28) | Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription factor MEF2C | Descriptor: | Focal adhesion kinase 1, MEF2C | Authors: | Cardoso, A.C, Ambrosio, A.L.B, Dessen, A, Franchini, K.G. | Deposit date: | 2015-12-01 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes. Structure, 24, 2016
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4BQM
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![BU of 4bqm by Molmil](/molmil-images/mine/4bqm) | Crystal structure of human liver-type glutaminase, catalytic domain | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLUTAMINASE LIVER ISOFORM, ... | Authors: | Ferreira, I.M, Vollmar, M, Krojer, T, Strain-Damerell, C, Froese, S, Coutandin, D, Williams, E, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Dias, S.M.G, Ambrosio, A.L.B, Yue, W.W. | Deposit date: | 2013-05-31 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Crystal Structure of Human Liver-Type Glutaminase, Catalytic Domain To be Published
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5U0K
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![BU of 5u0k by Molmil](/molmil-images/mine/5u0k) | C-terminal ankyrin repeats from human liver-type glutaminase (GAB/LGA) | Descriptor: | Glutaminase liver isoform, mitochondrial | Authors: | Ferreira, I.M, Pasquali, C.C, Gonzalez, A, Dias, S.M.G, Ambrosio, A.L.B. | Deposit date: | 2016-11-24 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.548 Å) | Cite: | The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. J. Biol. Chem., 292, 2017
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5U0J
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![BU of 5u0j by Molmil](/molmil-images/mine/5u0j) | C-terminal ankyrin repeats from human kidney-type glutaminase (KGA) - monoclinic crystal form | Descriptor: | Glutaminase kidney isoform, mitochondrial, SODIUM ION | Authors: | Pasquali, C.C, Gonzalez, A, Dias, S.M.G, Ambrosio, A.L.B. | Deposit date: | 2016-11-24 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. J. Biol. Chem., 292, 2017
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5UQE
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![BU of 5uqe by Molmil](/molmil-images/mine/5uqe) | Multidomain structure of human kidney-type glutaminase(KGA/GLS) | Descriptor: | Glutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide) | Authors: | Pasquali, C.C, Dias, S.M.G, Ambrosio, A.L.B. | Deposit date: | 2017-02-08 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. J. Biol. Chem., 292, 2017
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5U0I
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![BU of 5u0i by Molmil](/molmil-images/mine/5u0i) | C-terminal ankyrin repeats from human kidney-type glutaminase (KGA) - tetragonal crystal form | Descriptor: | CHLORIDE ION, Glutaminase kidney isoform, mitochondrial, ... | Authors: | Pasquali, C.C, Gonzalez, A, Dias, S.M.G, Ambrosio, A.L.B. | Deposit date: | 2016-11-24 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.423 Å) | Cite: | The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. J. Biol. Chem., 292, 2017
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2H77
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![BU of 2h77 by Molmil](/molmil-images/mine/2h77) | Crystal structure of human TR alpha bound T3 in monoclinic space group | Descriptor: | 3,5,3'TRIIODOTHYRONINE, THRA protein | Authors: | Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Bleicher, L, Ambrosio, A.L.B, Figueira, A.C.M, Santos, M.A.M, Neto, M.O, Fischer, H, Togashi, H.F.M, Craievich, A.F, Garrat, R.C, Baxter, J.D, Webb, P, Polikarpov, I. | Deposit date: | 2006-06-01 | Release date: | 2006-07-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J.Mol.Biol., 360, 2006
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2H79
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![BU of 2h79 by Molmil](/molmil-images/mine/2h79) | Crystal Structure of human TR alpha bound T3 in orthorhombic space group | Descriptor: | 3,5,3'TRIIODOTHYRONINE, THRA protein | Authors: | Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Bleicher, L, Ambrosio, A.L.B, Figueira, A.C.M, Santos, M.A.M, Neto, M.O, Fischer, H, Togashi, H.F.M, Craievich, A.F, Garrat, R.C, Baxter, J.D, Webb, P, Polikarpov, I. | Deposit date: | 2006-06-01 | Release date: | 2006-07-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J.Mol.Biol., 360, 2006
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8TNV
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![BU of 8tnv by Molmil](/molmil-images/mine/8tnv) | Hemocyanin Functional Unit CCHB-g of Concholepas concholepas | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Munoz, S, Vallejos-Baccelliere, G, Manubens, A, Salazar, M, Nascimento, A.F.Z, Ambrosio, A.L.B, Becker, M.I, Guixe, V, Castro-Fernandez, V. | Deposit date: | 2023-08-02 | Release date: | 2024-04-10 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural insights into a functional unit from an immunogenic mollusk hemocyanin. Structure, 32, 2024
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3SS4
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![BU of 3ss4 by Molmil](/molmil-images/mine/3ss4) | |
3SS5
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![BU of 3ss5 by Molmil](/molmil-images/mine/3ss5) | |
3SS3
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![BU of 3ss3 by Molmil](/molmil-images/mine/3ss3) | |
8EC6
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![BU of 8ec6 by Molmil](/molmil-images/mine/8ec6) | Cryo-EM structure of the Glutaminase C core filament (fGAC) | Descriptor: | Isoform 2 of Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION | Authors: | Ambrosio, A.L, Dias, S.M, Quesnay, J.E, Portugal, R.V, Cassago, A, van Heel, M.G, Islam, Z, Rodrigues, C.T. | Deposit date: | 2022-09-01 | Release date: | 2023-09-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection. Nat.Struct.Mol.Biol., 30, 2023
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4WN5
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![BU of 4wn5 by Molmil](/molmil-images/mine/4wn5) | Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol | Descriptor: | HEXAETHYLENE GLYCOL, Hypoxia-inducible factor 3-alpha, MONOVACCENIN, ... | Authors: | Fala, A.M, Oliveira, J.F, Dias, S.M, Ambrosio, A.L. | Deposit date: | 2014-10-10 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha. Sci Rep, 5, 2015
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3GWS
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![BU of 3gws by Molmil](/molmil-images/mine/3gws) | Crystal Structure of T3-Bound Thyroid Hormone Receptor | Descriptor: | 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor beta | Authors: | Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Polikarpov, I, Baxter, J.D, Webb, P. | Deposit date: | 2009-04-01 | Release date: | 2009-04-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function J.Mol.Biol., 360, 2006
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4JJM
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![BU of 4jjm by Molmil](/molmil-images/mine/4jjm) | Structure of a cyclophilin from Citrus sinensis (CsCyp) in complex with cyclosporin A | Descriptor: | Peptidyl-prolyl cis-trans isomerase, cyclosporin A | Authors: | Campos, B.M, Ambrosio, A.L.B, Souza, T.A.C.B, Barbosa, J.A.R.G, Benedetti, C.E. | Deposit date: | 2013-03-08 | Release date: | 2013-06-12 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | A redox 2-cys mechanism regulates the catalytic activity of divergent cyclophilins. Plant Physiol., 162, 2013
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4JKT
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![BU of 4jkt by Molmil](/molmil-images/mine/4jkt) | Crystal structure of mouse Glutaminase C, BPTES-bound form | Descriptor: | Glutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide) | Authors: | Fornezari, C, Ferreira, A.P.S, Dias, S.M.G, Ambrosio, A.L.B. | Deposit date: | 2013-03-11 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor. J.Biol.Chem., 288, 2013
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3FEX
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![BU of 3fex by Molmil](/molmil-images/mine/3fex) | |
3FEY
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![BU of 3fey by Molmil](/molmil-images/mine/3fey) | |
2HJH
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![BU of 2hjh by Molmil](/molmil-images/mine/2hjh) | Crystal Structure of the Sir2 deacetylase | Descriptor: | (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, NAD-dependent histone deacetylase SIR2, NICOTINAMIDE, ... | Authors: | Hall, B.E, Ellenberger, T.E. | Deposit date: | 2006-06-30 | Release date: | 2008-04-08 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site To be Published
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3ST1
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![BU of 3st1 by Molmil](/molmil-images/mine/3st1) | Crystal structure of Necrosis and Ethylene inducing Protein 2 from the causal agent of cocoa's Witches Broom disease | Descriptor: | Necrosis-and ethylene-inducing protein, SODIUM ION, ZINC ION | Authors: | Oliveira, J.F, Zaparoli, G, Barsottini, M.R.O, Ambrosio, A.L.B, Pereira, G.A.G, Dias, S.M.G. | Deposit date: | 2011-07-08 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of Necrosis- and Ethylene-Inducing Protein 2 from the Causal Agent of Cacao's Witches' Broom Disease Reveals Key Elements for Its Activity. Biochemistry, 50, 2011
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