8EC6

Cryo-EM structure of the Glutaminase C core filament (fGAC)

Summary for 8EC6

Entry DOI	10.2210/pdb8ec6/pdb
EMDB information	28013
Descriptor	Isoform 2 of Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION (2 entities in total)
Functional Keywords	mitochondria, filament, hydrolase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	8
Total formula weight	427375.46
Authors	Ambrosio, A.L.,Dias, S.M.,Quesnay, J.E.,Portugal, R.V.,Cassago, A.,van Heel, M.G.,Islam, Z.,Rodrigues, C.T. (deposition date: 2022-09-01, release date: 2023-09-20, Last modification date: 2023-12-27)
Primary citation	Adamoski, D.,Dias, M.M.,Quesnay, J.E.N.,Yang, Z.,Zagoriy, I.,Steyer, A.M.,Rodrigues, C.T.,da Silva Bastos, A.C.,da Silva, B.N.,Costa, R.K.E.,de Abreu, F.M.O.,Islam, Z.,Cassago, A.,van Heel, M.G.,Consonni, S.R.,Mattei, S.,Mahamid, J.,Portugal, R.V.,Ambrosio, A.L.B.,Dias, S.M.G. Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection. Nat.Struct.Mol.Biol., 30:1902-1912, 2023 Cited by PubMed: 37857822 DOI: 10.1038/s41594-023-01118-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation