Crystal structure of the CBC-importin alpha complex.

Summary for 3FEX

Related3FEX 3FEY
DescriptorNuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, Importin subunit alpha-2 (3 entities in total)
Functional Keywordscap binding complex, importin alpha, nuclear transport, coiled coil, mrna transport, nucleus, phosphoprotein, rna-binding, acetylation, cytoplasm, host-virus interaction, translation, protein transport
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q09161 P52298
Cytoplasm P52292
Total number of polymer chains3
Total molecular weight160767.96
Dias, S.M.G.,Ambrosio, A.L.B.,Cerione, R.A. (deposition date: 2008-12-01, release date: 2009-08-11, Last modification date: 2011-07-13)
Primary citation
Dias, S.M.,Wilson, K.F.,Rojas, K.S.,Ambrosio, A.L.,Cerione, R.A.
The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16:930-937, 2009
PubMed: 19668212 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.1649
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28711 1.0% 1.5% 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25