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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3FEX

Crystal structure of the CBC-importin alpha complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000245biological_processspliceosomal complex assembly
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000380biological_processalternative mRNA splicing, via spliceosome
A0000398biological_processmRNA splicing, via spliceosome
A0002191biological_processcap-dependent translational initiation
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005846cellular_componentnuclear cap binding complex
A0006370biological_process7-methylguanosine mRNA capping
A0006397biological_processmRNA processing
A0006401biological_processRNA catabolic process
A0006406biological_processmRNA export from nucleus
A0006408biological_processsnRNA export from nucleus
A0006417biological_processregulation of translation
A0006446biological_processregulation of translational initiation
A0008334biological_processhistone mRNA metabolic process
A0008380biological_processRNA splicing
A0016070biological_processRNA metabolic process
A0016071biological_processmRNA metabolic process
A0030307biological_processpositive regulation of cell growth
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031053biological_processprimary miRNA processing
A0031124biological_processmRNA 3'-end processing
A0031442biological_processpositive regulation of mRNA 3'-end processing
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034518cellular_componentRNA cap binding complex
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035195biological_processmiRNA-mediated post-transcriptional gene silencing
A0042789biological_processmRNA transcription by RNA polymerase II
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0050684biological_processregulation of mRNA processing
A0051028biological_processmRNA transport
A0051607biological_processdefense response to virus
A0060090molecular_functionmolecular adaptor activity
A1905216biological_processpositive regulation of RNA binding
A1990904cellular_componentribonucleoprotein complex
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000339molecular_functionRNA cap binding
B0000340molecular_functionRNA 7-methylguanosine cap binding
B0000380biological_processalternative mRNA splicing, via spliceosome
B0000398biological_processmRNA splicing, via spliceosome
B0002191biological_processcap-dependent translational initiation
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005846cellular_componentnuclear cap binding complex
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006408biological_processsnRNA export from nucleus
B0006417biological_processregulation of translation
B0006446biological_processregulation of translational initiation
B0008334biological_processhistone mRNA metabolic process
B0008380biological_processRNA splicing
B0016071biological_processmRNA metabolic process
B0017069molecular_functionsnRNA binding
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0031053biological_processprimary miRNA processing
B0031124biological_processmRNA 3'-end processing
B0031442biological_processpositive regulation of mRNA 3'-end processing
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034518cellular_componentRNA cap binding complex
B0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
B0035195biological_processmiRNA-mediated post-transcriptional gene silencing
B0036064cellular_componentciliary basal body
B0042789biological_processmRNA transcription by RNA polymerase II
B0045292biological_processmRNA cis splicing, via spliceosome
B0046833biological_processpositive regulation of RNA export from nucleus
B0051028biological_processmRNA transport
C0005737cellular_componentcytoplasm
C0006606biological_processprotein import into nucleus
C0061608molecular_functionnuclear import signal receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues17
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39603239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by RPS6KB1","evidences":[{"source":"PubMed","id":"10973943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12374755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12434151","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues39
DetailsRepeat: {"description":"ARM 2"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues41
DetailsRepeat: {"description":"ARM 3"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues36
DetailsRepeat: {"description":"ARM 5"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues39
DetailsRepeat: {"description":"ARM 6"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues39
DetailsRepeat: {"description":"ARM 7"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues42
DetailsRepeat: {"description":"ARM 8"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues46
DetailsRepeat: {"description":"ARM 9"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues39
DetailsRepeat: {"description":"ARM 10; atypical"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues88
DetailsRegion: {"description":"NLS binding site (minor)","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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