4WN5
Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol
Summary for 4WN5
| Entry DOI | 10.2210/pdb4wn5/pdb |
| Descriptor | Hypoxia-inducible factor 3-alpha, SULFATE ION, MONOVACCENIN, ... (5 entities in total) |
| Functional Keywords | hif-3alpha, pas domain, monoacylglycerol, lipid, fatty acid, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 27358.77 |
| Authors | Fala, A.M.,Oliveira, J.F.,Dias, S.M.,Ambrosio, A.L. (deposition date: 2014-10-10, release date: 2015-08-05, Last modification date: 2023-09-27) |
| Primary citation | Fala, A.M.,Oliveira, J.F.,Adamoski, D.,Aricetti, J.A.,Dias, M.M.,Dias, M.V.B.,Sforca, M.L.,Lopes-de-Oliveira, P.S.,Rocco, S.A.,Caldana, C.,Dias, S.M.G.,Ambrosio, A.L.B. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha. Sci Rep, 5:12698-12698, 2015 Cited by PubMed Abstract: Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia. PubMed: 26237540DOI: 10.1038/srep12698 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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