1EPA
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1EPB
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3O8Y
| Stable-5-Lipoxygenase | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Bartlett, S.G, Waight, M.T, Neau, D.B, Boeglin, W.E, Brash, A.R. | Deposit date: | 2010-08-03 | Release date: | 2011-01-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.389 Å) | Cite: | The structure of human 5-lipoxygenase. Science, 331, 2011
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6N2W
| The structure of Stable-5-Lipoxygenase bound to NDGA | Descriptor: | 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Neau, D.B. | Deposit date: | 2018-11-14 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat.Chem.Biol., 16, 2020
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6NCF
| The structure of Stable-5-Lipoxygenase bound to AKBA | Descriptor: | (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid, Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Neau, D.B. | Deposit date: | 2018-12-11 | Release date: | 2020-05-13 | Last modified: | 2020-07-08 | Method: | X-RAY DIFFRACTION (2.871 Å) | Cite: | Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat.Chem.Biol., 16, 2020
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1BI9
| RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND | Descriptor: | CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, RETINAL DEHYDROGENASE TYPE II | Authors: | Newcomer, M.E, Lamb, A.L. | Deposit date: | 1998-06-23 | Release date: | 1999-07-22 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity. Biochemistry, 38, 1999
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1FMJ
| CRYSTAL STRUCTURE OF MERCURY DERIVATIVE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, MERCURY (II) ION, ... | Authors: | Pakhomova, S, Kobayashi, M, Buck, J, Newcomer, M.E. | Deposit date: | 2000-08-17 | Release date: | 2001-05-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A helical lid converts a sulfotransferase to a dehydratase. Nat.Struct.Biol., 8, 2001
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4NRE
| The structure of human 15-lipoxygenase-2 with a substrate mimic | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, Arachidonate 15-lipoxygenase B, CALCIUM ION, ... | Authors: | Kobe, M.J, Neau, D.B, Mitchell, C.E, Bartlett, S.G, Newcomer, M.E. | Deposit date: | 2013-11-26 | Release date: | 2014-02-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | The structure of human 15-lipoxygenase-2 with a substrate mimic. J.Biol.Chem., 289, 2014
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2FNQ
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1I07
| EPS8 SH3 DOMAIN INTERTWINED DIMER | Descriptor: | EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8 | Authors: | Kishan, K.V.R, Newcomer, M.E. | Deposit date: | 2001-01-29 | Release date: | 2001-05-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain. Protein Sci., 10, 2001
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5DD8
| The Crystal structure of HucR mutant (HucR-E48Q) from Deinococcus radiodurans | Descriptor: | CHLORIDE ION, Transcriptional regulator, MarR family | Authors: | Deochand, D.K, Perera, I.C, Crochet, R.B, Gilbert, N.C, Newcomer, M.E, Grove, A. | Deposit date: | 2015-08-24 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices. Mol Biosyst, 12, 2016
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4HAI
| Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide. | Descriptor: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide, ... | Authors: | Pecic, S, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.D, Zhu, Z, Deng, S. | Deposit date: | 2012-09-26 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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1FML
| CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, RETINOL, ... | Authors: | Pakhomova, S, Kobayashi, M, Buck, J, Newcomer, M.E. | Deposit date: | 2000-08-17 | Release date: | 2001-05-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A helical lid converts a sulfotransferase to a dehydratase. Nat.Struct.Biol., 8, 2001
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5UYT
| Crystal structure of ice binding protein from an Antarctic bacterium Flavobacteriaceae | Descriptor: | Ice-binding protein, NITRATE ION | Authors: | Wang, C, Pakhomova, S, Newcomer, M.E, Christner, B.C, Luo, B.-H. | Deposit date: | 2017-02-24 | Release date: | 2017-10-25 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. PLoS ONE, 12, 2017
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4J03
| Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant | Descriptor: | (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | Authors: | Morisseau, C, Pakhomova, S, Hwang, S.H, Newcomer, M.E, Hammock, B.D. | Deposit date: | 2013-01-30 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg.Med.Chem.Lett., 23, 2013
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4KUM
| Structure of LSD1-CoREST-Tetrahydrofolate complex | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Calcutt, M.W, Newcomer, M.E, Wagner, C. | Deposit date: | 2013-05-22 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci., 23, 2014
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1X8J
| Crystal structure of retinol dehydratase in complex with androsterone and inactive cofactor PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Androsterone, CALCIUM ION, ... | Authors: | Pakhomova, S, Buck, J, Newcomer, M.E. | Deposit date: | 2004-08-18 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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1X8L
| Crystal structure of retinol dehydratase in complex with all-trans-4-oxoretinol and inactive cofactor PAP | Descriptor: | 4-OXORETINOL, ADENOSINE-3'-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Pakhomova, S, Buck, J, Newcomer, M.E. | Deposit date: | 2004-08-18 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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7TTL
| Stable-5-LOX elongated Ha2 (4 copies ASU) | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Gilbert, N.C, Newcomer, M.E. | Deposit date: | 2022-02-01 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators. J.Biol.Chem., 298, 2022
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7TTJ
| Stable-5-LOX elongated Ha2 | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Gilbert, N.C, Newcomer, M.E. | Deposit date: | 2022-02-01 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators. J.Biol.Chem., 298, 2022
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1X8K
| Crystal structure of retinol dehydratase in complex with anhydroretinol and inactive cofactor PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, ANHYDRORETINOL, CALCIUM ION, ... | Authors: | Pakhomova, S, Buck, J, Newcomer, M.E. | Deposit date: | 2004-08-18 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition. Protein Sci., 14, 2005
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6AUM
| Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid. | Descriptor: | 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid, Bifunctional epoxide hydrolase 2, CHLORIDE ION, ... | Authors: | Kodani, S.D, Bahkta, S, Hwang, S.H, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B. | Deposit date: | 2017-09-01 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg. Med. Chem. Lett., 28, 2018
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3V99
| S663D Stable-5-LOX in complex with Arachidonic Acid | Descriptor: | ARACHIDONIC ACID, Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | Deposit date: | 2011-12-23 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Faseb J., 26, 2012
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3V92
| S663A Stable-5-LOX | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | Deposit date: | 2011-12-23 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Faseb J., 26, 2012
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3V98
| S663D Stable-5-LOX | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Gilbert, N.C, Rui, Z, Neau, D.B, Waight, M, Bartlett, S.G, Boeglin, W.E, Brash, A.R, Newcomer, M.E. | Deposit date: | 2011-12-23 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Faseb J., 26, 2012
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