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6N2W

The structure of Stable-5-Lipoxygenase bound to NDGA

Summary for 6N2W
Entry DOI10.2210/pdb6n2w/pdb
DescriptorArachidonate 5-lipoxygenase, FE (II) ION, 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, ... (4 entities in total)
Functional Keywordslipoxygenase, inhibitor, allostery, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight159286.54
Authors
Newcomer, M.E.,Gilbert, N.C.,Neau, D.B. (deposition date: 2018-11-14, release date: 2020-05-13, Last modification date: 2023-10-11)
Primary citationGilbert, N.C.,Gerstmeier, J.,Schexnaydre, E.E.,Borner, F.,Garscha, U.,Neau, D.B.,Werz, O.,Newcomer, M.E.
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nat.Chem.Biol., 16:783-790, 2020
Cited by
PubMed: 32393899
DOI: 10.1038/s41589-020-0544-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.71 Å)
Structure validation

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