3V99

S663D Stable-5-LOX in complex with Arachidonic Acid

Summary for 3V99

• Entry DOI: 10.2210/pdb3v99/pdb
• Related: 3O8Y 3V92 3V98
• Descriptor: Arachidonate 5-lipoxygenase, FE (II) ION, ARACHIDONIC ACID, ... (4 entities in total)
• Functional Keywords: lipoxygenase, dioxygenase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P09917
• Total number of polymer chains: 2
• Total formula weight: 159344.66

Authors

Gilbert, N.C.,Rui, Z.,Neau, D.B.,Waight, M.,Bartlett, S.G.,Boeglin, W.E.,Brash, A.R.,Newcomer, M.E. (deposition date: 2011-12-23, release date: 2012-05-02, Last modification date: 2024-02-28)

• Primary citation: Gilbert, N.C.,Rui, Z.,Neau, D.B.,Waight, M.T.,Bartlett, S.G.,Boeglin, W.E.,Brash, A.R.,Newcomer, M.E.; Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.; Faseb J., 26:3222-3229, 2012; PubMed: 22516296; DOI: 10.1096/fj.12-205286

Experimental method

X-RAY DIFFRACTION (2.252 Å)