3V99
S663D Stable-5-LOX in complex with Arachidonic Acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Arachidonate 5-lipoxygenase | polymer | 691 | 79464.3 | 2 | UniProt (P09917) Pfam (PF01477) Pfam (PF00305) | Homo sapiens (human) | 5-LO, 5-lipoxygenase |
| 2 | C, E (A, B) | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) PubChem (27284) | |||
| 3 | D (A) | ARACHIDONIC ACID | non-polymer | 304.5 | 1 | Chemie (ACD) PubChem (114670) PubChem (444899) PubChem (5312542) PubChem (231) PubChem (87131823) PubChem (87196993) PubChem (92449654) PubChem (12083498) PubChem (12096305) PubChem (12111897) PubChem (12183869) PubChem (12358407) PubChem (12358409) PubChem (12358410) PubChem (12358414) PubChem (12990988) PubChem (122652008) PubChem (122651992) PubChem (122652036) PubChem (122652077) PubChem (173636367) PubChem (173785266) PubChem (174059456) PubChem (175709969) PubChem (175736020) PubChem (175951410) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 392 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 673 (UniProt: P09917)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Val -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| His 2 | - | expression tag |
| Glu 16 | Trp 14 | engineered mutation |
| His 17 | Phe 15 | engineered mutation |
| Gly 43 | Asn 44 | SEE REMARK 999 |
| Ser 44 | Asp 45 | SEE REMARK 999 |
| Gly 75 | Trp 76 | engineered mutation |
| Ser 76 | Leu 77 | engineered mutation |
| Ala 240 | Cys 241 | engineered mutation |
| Ala 561 | Cys 562 | engineered mutation |
| Glu 653 | Lys 654 | engineered mutation |
| Asn 654 | Lys 655 | engineered mutation |
| Leu 655 | Lys 656 | engineered mutation |
| Asp 663 | Ser 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 158928.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 416.2 | |
| All* | Total formula weight | 159344.7 |
