6AUM

Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.

Summary for 6AUM

Entry DOI	10.2210/pdb6aum/pdb
Descriptor	Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	soluble epoxide hydrolase, urea inhibitors, neuropathic pain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	63349.65
Authors	Kodani, S.D.,Bahkta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B. (deposition date: 2017-09-01, release date: 2018-02-07, Last modification date: 2023-10-04)
Primary citation	Kodani, S.D.,Bhakta, S.,Hwang, S.H.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B.D. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg. Med. Chem. Lett., 28:762-768, 2018 Cited by PubMed: 29366648 DOI: 10.1016/j.bmcl.2018.01.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation