4HAI

Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.

Summary for 4HAI

Entry DOI	10.2210/pdb4hai/pdb
Descriptor	Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	domain-swapped dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P34913
Total number of polymer chains	1
Total formula weight	63211.47
Authors	Pecic, S.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B.D.,Zhu, Z.,Deng, S. (deposition date: 2012-09-26, release date: 2012-12-26, Last modification date: 2023-09-20)
Primary citation	Pecic, S.,Pakhomova, S.,Newcomer, M.E.,Morisseau, C.,Hammock, B.D.,Zhu, Z.,Rinderspacher, A.,Deng, S.X. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg.Med.Chem.Lett., 23:417-421, 2013 Cited by PubMed: 23237835 DOI: 10.1016/j.bmcl.2012.11.084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation