4KUM

Structure of LSD1-CoREST-Tetrahydrofolate complex

Summary for 4KUM

• Entry DOI: 10.2210/pdb4kum/pdb
• Related: 2H94 2HKO 2IW5 2UXX 2V1D
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: histone demethylase, folate binding, chromatin, nucleosomes, oxidoreductase-transcription regulator complex, oxidoreductase/transcription regulator
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O60341
• Total number of polymer chains: 2
• Total formula weight: 101911.04

Authors

Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Calcutt, M.W.,Newcomer, M.E.,Wagner, C. (deposition date: 2013-05-22, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Calcutt, M.W.,Newcomer, M.E.,Wagner, C.; Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate.; Protein Sci., 23:993-998, 2014; PubMed: 24715612; DOI: 10.1002/pro.2469

Experimental method

X-RAY DIFFRACTION (3.05 Å)