4KUM
Structure of LSD1-CoREST-Tetrahydrofolate complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 666 | 74126.8 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (human) | BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | B (B) | REST corepressor 1 | polymer | 235 | 26425.7 | 1 | UniProt (J3KN32) Pfam (PF20878) Pfam (PF00249) UniProt (by SIFTS) (Q9UKL0) | Homo sapiens (human) | REST corepressor 1, isoform CRA_a |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | (6S)-5,6,7,8-TETRAHYDROFOLATE | non-polymer | 445.4 | 1 | Chemie (THG) | |||
| 6 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | G (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
B: 286 - 482 (UniProt: J3KN32)
| PDB | External Database | Details |
|---|---|---|
| Met 248 | - | expression tag |
| Gly 249 | - | expression tag |
| Ser 250 | - | expression tag |
| Ser 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
| His 256 | - | expression tag |
| His 257 | - | expression tag |
| Ser 258 | - | expression tag |
| Ser 259 | - | expression tag |
| Gly 260 | - | expression tag |
| Leu 261 | - | expression tag |
| Val 262 | - | expression tag |
| Pro 263 | - | expression tag |
| Arg 264 | - | expression tag |
| Gly 265 | - | expression tag |
| Ser 266 | - | expression tag |
| His 267 | - | expression tag |
| Met 268 | - | expression tag |
| Ala 269 | - | expression tag |
| Ser 270 | - | expression tag |
| Met 271 | - | expression tag |
| Thr 272 | - | expression tag |
| Gly 273 | - | expression tag |
| Gly 274 | - | expression tag |
| Gln 275 | - | expression tag |
| Gln 276 | - | expression tag |
| Met 277 | - | expression tag |
| Gly 278 | - | expression tag |
| Arg 279 | - | expression tag |
| Gly 280 | - | expression tag |
| Ser 281 | - | expression tag |
| Glu 282 | - | expression tag |
| Phe 283 | - | expression tag |
| Gly 284 | - | expression tag |
| Arg 285 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 100552.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1358.5 | |
| All* | Total formula weight | 101911.0 |
