8DFP
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![BU of 8dfp by Molmil](/molmil-images/mine/8dfp) | Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | Authors: | Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J. | Deposit date: | 2022-06-22 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proc.Natl.Acad.Sci.USA, 120, 2023
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6V46
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![BU of 6v46 by Molmil](/molmil-images/mine/6v46) | The crystal structure of hemagglutinin from A/turkey/Ontario/6118/1968 (H8N4) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, H, Stevens, J. | Deposit date: | 2019-11-27 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.248 Å) | Cite: | Molecular characterization and three-dimensional structures of avian H8, H11, H14, H15 and swine H4 influenza virus hemagglutinins Heliyon, 6, 2020
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6V49
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![BU of 6v49 by Molmil](/molmil-images/mine/6v49) | The crystal structure of hemagglutinin from A/wedge-tailed shearwater/Western Australia/2576/1979 (H15N9) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | Authors: | Yang, H, Stevens, J. | Deposit date: | 2019-11-27 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular characterization and three-dimensional structures of avian H8, H11, H14, H15 and swine H4 influenza virus hemagglutinins Heliyon, 6, 2020
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6P2L
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![BU of 6p2l by Molmil](/molmil-images/mine/6p2l) | Crystal structure of Niastella koreensis GH74 (NkGH74) enzyme | Descriptor: | CHLORIDE ION, Glycosyl hydrolase BNR repeat-containing protein, alpha-D-xylopyranose-(1-6)-beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, ... | Authors: | Stogios, P.J, Skarina, T, Arnal, G, Brumer, H, Savchenko, A. | Deposit date: | 2019-05-21 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74. J.Biol.Chem., 294, 2019
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6P2N
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![BU of 6p2n by Molmil](/molmil-images/mine/6p2n) | Crystal structure of Paenibacillus graminis GH74 (PgGH74) | Descriptor: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Stogios, P.J. | Deposit date: | 2019-05-21 | Release date: | 2019-07-31 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74. J.Biol.Chem., 294, 2019
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6VOV
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![BU of 6vov by Molmil](/molmil-images/mine/6vov) | Crystal structure of Syk in complex with GS-9876 | Descriptor: | 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine, Tyrosine-protein kinase SYK | Authors: | Lansdon, E.B. | Deposit date: | 2020-01-31 | Release date: | 2020-03-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. Acs Med.Chem.Lett., 11, 2020
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6YI3
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![BU of 6yi3 by Molmil](/molmil-images/mine/6yi3) | |
6Z1Z
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![BU of 6z1z by Molmil](/molmil-images/mine/6z1z) | Structure of the anti-CD9 nanobody 4C8 | Descriptor: | Nanobody 4C8 | Authors: | Neviani, N, Oosterheert, W, Pearce, N.M, Lutz, M, Kroon-Batenburg, L.M.J, Gros, P. | Deposit date: | 2020-05-14 | Release date: | 2020-09-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Sci Alliance, 3, 2020
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5UKP
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![BU of 5ukp by Molmil](/molmil-images/mine/5ukp) | Structure of unliganded anti-gp120 CD4bs antibody DH522.1 Fab | Descriptor: | DH522.1 Fab fragment heavy chain, DH522.1 Fab fragment light chain | Authors: | Nicely, N.I. | Deposit date: | 2017-01-23 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun, 8, 2017
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5UKN
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![BU of 5ukn by Molmil](/molmil-images/mine/5ukn) | Structure of unliganded anti-gp120 CD4bs antibody DH522UCA Fab | Descriptor: | CHLORIDE ION, DH522UCA Fab fragment heavy chain, DH522UCA Fab fragment light chain | Authors: | Nicely, N.I. | Deposit date: | 2017-01-23 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun, 8, 2017
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5C91
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![BU of 5c91 by Molmil](/molmil-images/mine/5c91) | NEDD4 HECT with covalently bound indole-based inhibitor | Descriptor: | E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate | Authors: | Span, I, Smith, A.T, Kathman, S, Statsyuk, A.V, Rosenzweig, A.C. | Deposit date: | 2015-06-26 | Release date: | 2015-09-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc., 137, 2015
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5K7K
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![BU of 5k7k by Molmil](/molmil-images/mine/5k7k) | |
6Z1V
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![BU of 6z1v by Molmil](/molmil-images/mine/6z1v) | Structure of the EC2 domain of CD9 in complex with nanobody 4E8 | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CD9 antigen, ... | Authors: | Oosterheert, W, Pearce, N.M, Gros, P. | Deposit date: | 2020-05-14 | Release date: | 2020-09-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Sci Alliance, 3, 2020
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7LDG
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![BU of 7ldg by Molmil](/molmil-images/mine/7ldg) | Crystal structure of the MEILB2-BRCA2 complex | Descriptor: | Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein | Authors: | Nandakumar, J, Pendlebury, D.F. | Deposit date: | 2021-01-13 | Release date: | 2021-08-11 | Last modified: | 2021-08-25 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. Nat.Struct.Mol.Biol., 28, 2021
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2K3O
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![BU of 2k3o by Molmil](/molmil-images/mine/2k3o) | |
8EFP
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![BU of 8efp by Molmil](/molmil-images/mine/8efp) | |
5T7F
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![BU of 5t7f by Molmil](/molmil-images/mine/5t7f) | PI3Kdelta in complex with the inhibitor GS-643624 | Descriptor: | 2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Authors: | Somoza, J.R, Villasenor, A. | Deposit date: | 2016-09-04 | Release date: | 2016-12-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd To Be Published
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4AIU
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![BU of 4aiu by Molmil](/molmil-images/mine/4aiu) | A complex structure of BtGH84 | Descriptor: | (3AR,5R,6S,7R,7AR)-2,5-BIS(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]OXAZOLE-6,7-DIOL, CALCIUM ION, O-GLCNACASE BT_4395 | Authors: | He, Y, Davies, G.J. | Deposit date: | 2012-02-13 | Release date: | 2012-06-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase. J.Biol.Chem., 287, 2012
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5UKR
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![BU of 5ukr by Molmil](/molmil-images/mine/5ukr) | |
7LIR
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![BU of 7lir by Molmil](/molmil-images/mine/7lir) | Structure of the invertebrate ALK GRD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor homolog scd-2, ... | Authors: | Stayrook, S, Li, T, Klein, D.E. | Deposit date: | 2021-01-27 | Release date: | 2021-11-24 | Last modified: | 2021-12-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for ligand reception by anaplastic lymphoma kinase. Nature, 600, 2021
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7LS0
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![BU of 7ls0 by Molmil](/molmil-images/mine/7ls0) | Structure of the Human ALK GRD bound to AUG | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor fused with ALK and LTK ligand 2, CITRIC ACID | Authors: | Stayrook, S, Li, T, Klein, D.E. | Deposit date: | 2021-02-17 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural basis for ligand reception by anaplastic lymphoma kinase. Nature, 600, 2021
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5UKO
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![BU of 5uko by Molmil](/molmil-images/mine/5uko) | Structure of unliganded anti-gp120 CD4bs antibody DH522IA Fab | Descriptor: | DH522IA Fab fragment heavy chain, DH522IA Fab fragment light chain | Authors: | Nicely, N.I. | Deposit date: | 2017-01-23 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun, 8, 2017
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7LRZ
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![BU of 7lrz by Molmil](/molmil-images/mine/7lrz) | Structure of the Human ALK GRD | Descriptor: | ALK tyrosine kinase receptor | Authors: | Stayrook, S, Li, T, Klein, D.E. | Deposit date: | 2021-02-17 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structural basis for ligand reception by anaplastic lymphoma kinase. Nature, 600, 2021
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7RR9
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![BU of 7rr9 by Molmil](/molmil-images/mine/7rr9) | Cryo-EM Structure of Nanodisc reconstituted ABCD1 in nucleotide bound outward open conformation | Descriptor: | ATP-binding cassette sub-family D member 1, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Alam, A, Le, L.T.M, Thompson, J.R. | Deposit date: | 2021-08-09 | Release date: | 2022-01-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment Commun Biol, 5, 2022
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6ZFM
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![BU of 6zfm by Molmil](/molmil-images/mine/6zfm) | Structure of alpha-Cobratoxin with a peptide inhibitor | Descriptor: | 3-[2-[2-[2-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propan-1-ol, Alpha-cobratoxin, PENTAETHYLENE GLYCOL, ... | Authors: | Kiontke, S, Kummel, D. | Deposit date: | 2020-06-17 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Peptide Inhibitors of the alpha-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction. J.Med.Chem., 63, 2020
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