6VOV
Crystal structure of Syk in complex with GS-9876
Summary for 6VOV
Entry DOI | 10.2210/pdb6vov/pdb |
Descriptor | Tyrosine-protein kinase SYK, 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine (3 entities in total) |
Functional Keywords | spleen tyrosine kinase b-cell syk, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 66256.19 |
Authors | Lansdon, E.B. (deposition date: 2020-01-31, release date: 2020-03-11, Last modification date: 2023-10-11) |
Primary citation | Blomgren, P.,Chandrasekhar, J.,Di Paolo, J.A.,Fung, W.,Geng, G.,Ip, C.,Jones, R.,Kropf, J.E.,Lansdon, E.B.,Lee, S.,Lo, J.R.,Mitchell, S.A.,Murray, B.,Pohlmeyer, C.,Schmitt, A.,Suekawa-Pirrone, K.,Wise, S.,Xiong, J.M.,Xu, J.,Yu, H.,Zhao, Z.,Currie, K.S. Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. Acs Med.Chem.Lett., 11:506-513, 2020 Cited by PubMed: 32292557DOI: 10.1021/acsmedchemlett.9b00621 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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