6VOV

Crystal structure of Syk in complex with GS-9876

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase SYK	polymer	281	32684.6	2	UniProt (P43405) Pfam (PF07714)	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	C, D (A, B)	6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine	non-polymer		443.5	2	Chemie (R6D)
3	E, F (A, B)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, B: 363 - 635 (UniProt: P43405)

PDB	External Database	Details
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65369.2
Non-Polymers*	Number of molecules	2
	Total formula weight	887.0
All*	Total formula weight	66256.2

*Water molecules are not included.