8EFP

CryoEM structure of GSDMB in complex with shigella IpaH7.8

Summary for 8EFP

Entry DOI	10.2210/pdb8efp/pdb
EMDB information	28087
Descriptor	Probable E3 ubiquitin-protein ligase ipaH7.8, Gasdermin-B (2 entities in total)
Functional Keywords	gsdmb, gsdmd, pyroptosis, ubiquitination, antimicrobial protein, transferase-lipid binding protein complex, transferase/lipid binding protein
Biological source	Shigella flexneri More
Total number of polymer chains	2
Total formula weight	112013.81
Authors	Wang, C.,Ruan, J. (deposition date: 2022-09-08, release date: 2023-03-29, Last modification date: 2023-05-03)
Primary citation	Wang, C.,Shivcharan, S.,Tian, T.,Wright, S.,Ma, D.,Chang, J.,Li, K.,Song, K.,Xu, C.,Rathinam, V.A.,Ruan, J. Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Nature, 616:590-597, 2023 Cited by PubMed: 36991122 DOI: 10.1038/s41586-023-05832-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation