7YVI
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![BU of 7yvi by Molmil](/molmil-images/mine/7yvi) | Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH236 Fab heavy chain, ... | Authors: | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | Deposit date: | 2022-08-19 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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2AOC
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![BU of 2aoc by Molmil](/molmil-images/mine/2aoc) | Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOG
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![BU of 2aog by Molmil](/molmil-images/mine/2aog) | Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC | Descriptor: | ACETIC ACID, GLYCEROL, HIV-1 PROTEASE (RETROPEPSIN), ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOD
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![BU of 2aod by Molmil](/molmil-images/mine/2aod) | Crystal structure analysis of HIV-1 protease with a substrate analog P2-NC | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, HIV-1 PROTEASE, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOJ
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![BU of 2aoj by Molmil](/molmil-images/mine/2aoj) | Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR | Descriptor: | ACETIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOE
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![BU of 2aoe by Molmil](/molmil-images/mine/2aoe) | crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2 | Descriptor: | ACETIC ACID, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOF
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![BU of 2aof by Molmil](/molmil-images/mine/2aof) | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P1-P6 | Descriptor: | ACETIC ACID, CHLORIDE ION, PEPTIDE INHIBITOR, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOI
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![BU of 2aoi by Molmil](/molmil-images/mine/2aoi) | Crystal structure analysis of HIV-1 protease with a substrate analog P1-P6 | Descriptor: | PEPTIDE INHIBITOR, POL POLYPROTEIN, SULFATE ION | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AOH
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![BU of 2aoh by Molmil](/molmil-images/mine/2aoh) | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR | Descriptor: | CHLORIDE ION, PEPTIDE INHIBITOR, POL POLYPROTEIN, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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3OKX
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![BU of 3okx by Molmil](/molmil-images/mine/3okx) | Crystal structure of YaeB-like protein from Rhodopseudomonas palustris | Descriptor: | S-ADENOSYLMETHIONINE, YaeB-like protein RPA0152 | Authors: | Chang, C, Evdokimova, E, Liu, F, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-08-25 | Release date: | 2010-09-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of YaeB-like protein from Rhodopseudomonas palustris To be Published
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5W81
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![BU of 5w81 by Molmil](/molmil-images/mine/5w81) | Phosphorylated, ATP-bound structure of zebrafish cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Zhang, Z, Liu, F, Chen, J. | Deposit date: | 2017-06-21 | Release date: | 2017-07-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Conformational Changes of CFTR upon Phosphorylation and ATP Binding. Cell, 170, 2017
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3RJW
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![BU of 3rjw by Molmil](/molmil-images/mine/3rjw) | Crystal structure of histone lysine methyltransferase g9a with an inhibitor | Descriptor: | 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)piperidin-4-yl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Dong, A, Wasney, G.A, Tempel, W, Liu, F, Barsyte, D, Allali-Hassani, A, Chen, X, Chau, I, Hajian, T, Senisterra, G, Chavda, N, Arora, K, Siarheyeva, A, Kireev, D.B, Herold, J.M, Bochkarev, A, Bountra, C, Weigelt, J, Edwards, A.M, Frye, S.V, Arrowsmith, C.H, Brown, P.J, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) | Deposit date: | 2011-04-15 | Release date: | 2011-05-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol., 7, 2011
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6M71
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![BU of 6m71 by Molmil](/molmil-images/mine/6m71) | SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase | Authors: | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | Deposit date: | 2020-03-16 | Release date: | 2020-04-01 | Last modified: | 2021-03-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368, 2020
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3PF6
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![BU of 3pf6 by Molmil](/molmil-images/mine/3pf6) | The structure of uncharacterized protein PP-LUZ7_gp033 from Pseudomonas phage LUZ7. | Descriptor: | CHLORIDE ION, hypothetical protein PP-LUZ7_gp033 | Authors: | Cuff, M.E, Evdokimova, E, Liu, F, Edwards, A, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-10-28 | Release date: | 2010-11-10 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structure of uncharacterized protein PP-LUZ7_gp033 from Pseudomonas phage LUZ7. TO BE PUBLISHED
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6BVP
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![BU of 6bvp by Molmil](/molmil-images/mine/6bvp) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase N27A from Cupriavidus metallidurans | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION | Authors: | Yang, Y, Liu, F, Liu, A. | Deposit date: | 2017-12-13 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
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6BVQ
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![BU of 6bvq by Molmil](/molmil-images/mine/6bvq) | Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase N27A from Cupriavidus metallidurans in complex with 4-Cl-3-HAA | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, 4-CHLORO-3-HYDROXYANTHRANILIC ACID, ... | Authors: | Yang, Y, Liu, F, Liu, A. | Deposit date: | 2017-12-13 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.084 Å) | Cite: | Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. J. Biol. Chem., 293, 2018
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3QTD
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![BU of 3qtd by Molmil](/molmil-images/mine/3qtd) | Crystal structure of putative modulator of gyrase (PmbA) from Pseudomonas aeruginosa PAO1 | Descriptor: | GLYCEROL, PmbA protein | Authors: | Tkaczuk, K.L, Chruszcz, M, Evdokimova, E, Liu, F, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-02-22 | Release date: | 2011-03-30 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of putative modulator of gyrase (PmbA) from Pseudomonas aeruginosa PAO1 To be Published
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2ELA
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![BU of 2ela by Molmil](/molmil-images/mine/2ela) | Crystal Structure of the PTB domain of human APPL1 | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | Deposit date: | 2007-03-27 | Release date: | 2007-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
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2ELB
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![BU of 2elb by Molmil](/molmil-images/mine/2elb) | Crystal Structure of the BAR-PH domain of human APPL1 | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | Deposit date: | 2007-03-27 | Release date: | 2007-05-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
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5TCD
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![BU of 5tcd by Molmil](/molmil-images/mine/5tcd) | Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Liu, F, Illes, K, Nagar, B. | Deposit date: | 2016-09-14 | Release date: | 2017-03-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. J. Biol. Chem., 292, 2017
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2HS2
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![BU of 2hs2 by Molmil](/molmil-images/mine/2hs2) | Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir) | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Weber, I.T, Kovalevsky, A.Y, Liu, F. | Deposit date: | 2006-07-20 | Release date: | 2006-10-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. J.Mol.Biol., 363, 2006
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8HPR
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![BU of 8hpr by Molmil](/molmil-images/mine/8hpr) | LpqY-SugABC in state 4 | Descriptor: | ABC sugar transporter, permease component, ABC transporter, ... | Authors: | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | Deposit date: | 2022-12-12 | Release date: | 2023-09-06 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPM
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![BU of 8hpm by Molmil](/molmil-images/mine/8hpm) | LpqY-SugABC in state 2 | Descriptor: | ABC sugar transporter, permease component, ABC transporter, ... | Authors: | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | Deposit date: | 2022-12-12 | Release date: | 2023-09-06 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPN
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![BU of 8hpn by Molmil](/molmil-images/mine/8hpn) | LpqY-SugABC in state 3 | Descriptor: | ABC sugar transporter, permease component, ABC transporter, ... | Authors: | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | Deposit date: | 2022-12-12 | Release date: | 2023-09-06 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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8HPS
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![BU of 8hps by Molmil](/molmil-images/mine/8hps) | LpqY-SugABC in state 5 | Descriptor: | ABC sugar transporter, permease component, ABC transporter, ... | Authors: | Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. | Deposit date: | 2022-12-12 | Release date: | 2023-09-06 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
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