2HS2
Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)
Summary for 2HS2
Entry DOI | 10.2210/pdb2hs2/pdb |
Related | 2HS1 |
Descriptor | protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (5 entities in total) |
Functional Keywords | aspartic protease active site surface binding site, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22689.65 |
Authors | Weber, I.T.,Kovalevsky, A.Y.,Liu, F. (deposition date: 2006-07-20, release date: 2006-10-03, Last modification date: 2024-02-14) |
Primary citation | Kovalevsky, A.Y.,Liu, F.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. J.Mol.Biol., 363:161-173, 2006 Cited by PubMed: 16962136DOI: 10.1016/j.jmb.2006.08.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.22 Å) |
Structure validation
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