5TCD

Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine

Summary for 5TCD

Entry DOI	10.2210/pdb5tcd/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	sphingomyelinase, sphingomyelin, phosphocholine, glycosylphosphatidylinositol, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	55640.03
Authors	Gorelik, A.,Liu, F.,Illes, K.,Nagar, B. (deposition date: 2016-09-14, release date: 2017-03-22, Last modification date: 2020-07-29)
Primary citation	Gorelik, A.,Liu, F.,Illes, K.,Nagar, B. Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. J. Biol. Chem., 292:7087-7094, 2017 Cited by PubMed: 28292932 DOI: 10.1074/jbc.M116.769273 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation