2AOC

Crystal structure analysis of HIV-1 protease mutant I84V with a substrate analog P2-NC

Summary for 2AOC

• Entry DOI: 10.2210/pdb2aoc/pdb
• Related: 1FGC 2AOD 2AOE 2AOF 2AOG 2AOH 2AOI 2AOJ
• Related PRD ID: PRD_000398
• Descriptor: HIV-1 PROTEASE, UNKNOWN ATOM OR ION, SODIUM ION, ... (8 entities in total)
• Functional Keywords: hiv-1 protease, mutant, dimer, substrate analog, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (BH5 ISOLATE)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22772.22

Authors

Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-12, release date: 2006-01-17, Last modification date: 2024-03-13)

• Primary citation: Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T.; Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.; Febs J., 272:5265-5277, 2005; PubMed: 16218957; DOI: 10.1111/j.1742-4658.2005.04923.x

Experimental method

X-RAY DIFFRACTION (1.3 Å)