2AOE

crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog CA-P2

Summary for 2AOE

• Entry DOI: 10.2210/pdb2aoe/pdb
• Related: 1A8K 1A94 2AOC 2AOD 2AOF 2AOG 2AOH 2AOI 2AOJ
• Related PRD ID: PRD_000349
• Descriptor: POL POLYPROTEIN, SODIUM ION, CHLORIDE ION, ... (8 entities in total)
• Functional Keywords: hiv-1 protease, substrate analog, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (BH5 ISOLATE)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587
• Total number of polymer chains: 2
• Total formula weight: 22802.12

Authors

Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-12, release date: 2006-01-17, Last modification date: 2023-08-23)

• Primary citation: Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Liu, F.,Chen, X.,Tozser, J.,Harrison, R.W.,Weber, I.T.; Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.; Febs J., 272:5265-5277, 2005; PubMed: 16218957; DOI: 10.1111/j.1742-4658.2005.04923.x

Experimental method

X-RAY DIFFRACTION (1.54 Å)