1A94
STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Summary for 1A94
Entry DOI | 10.2210/pdb1a94/pdb |
Related PRD ID | PRD_000349 |
Descriptor | PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total) |
Functional Keywords | human immunodeficiency virus protease, rous sarcoma virus protease, protein-mediated interaction, viral maturation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 4 |
Total formula weight | 44628.55 |
Authors | Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. (deposition date: 1998-04-16, release date: 1999-01-13, Last modification date: 2024-02-07) |
Primary citation | Wu, J.,Adomat, J.M.,Ridky, T.W.,Louis, J.M.,Leis, J.,Harrison, R.W.,Weber, I.T. Structural basis for specificity of retroviral proteases. Biochemistry, 37:4518-4526, 1998 Cited by PubMed: 9521772DOI: 10.1021/bi972183g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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