9BKN
 
 | DHODH in complex with Ligand 16 | Descriptor: | (2P,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-(propan-2-yl)isoquinolin-1(2H)-one, ACETATE ION, CHLORIDE ION, ... | Authors: | Shaffer, P.L. | Deposit date: | 2024-04-29 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. J.Med.Chem., 67, 2024
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9BKO
 
 | DHODH in complex with Ligand 26 | Descriptor: | (2P,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-[(2R)-1,1,1-trifluoropropan-2-yl]isoquinolin-1(2H)-one, ACETATE ION, CHLORIDE ION, ... | Authors: | Shaffer, P.L. | Deposit date: | 2024-04-29 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML. J.Med.Chem., 67, 2024
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7S0V
 
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6L4X
 
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2QRV
 
 | Structure of Dnmt3a-Dnmt3L C-terminal domain complex | Descriptor: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Jia, D, Cheng, X. | Deposit date: | 2007-07-29 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
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3NER
 
 | Structure of Human Type B Cytochrome b5 | Descriptor: | Cytochrome b5 type B, MAGNESIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Terzyan, S, Zhang, C, Rivera, M, Benson, D.B. | Deposit date: | 2010-06-09 | Release date: | 2011-05-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Accommodating a Non-Conservative Internal Mutation by Water-Mediated Hydrogen-Bonding Between beta-Sheet Strands: A Comparison of Human and Rat Type B (Mitochondrial) Cytochrome b5 Biochemistry, 50, 2011
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3K1Q
 
 | Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics | Descriptor: | Core protein VP6, Outer capsid VP5, Outer capsid VP7, ... | Authors: | Cheng, L.P, Zhu, J, Hiu, W.H, Zhang, X.K, Honig, B, Fang, Q, Zhou, Z.H. | Deposit date: | 2009-09-28 | Release date: | 2010-03-23 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Backbone Model of an Aquareovirus Virion by Cryo-Electron Microscopy and Bioinformatics J.Mol.Biol., 397, 2010
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5GZO
 
 | Structure of neutralizing antibody bound to Zika envelope protein | Descriptor: | Antibody heavy chain, Antibody light chain, Genome polyprotein | Authors: | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2016-09-29 | Release date: | 2017-01-18 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.755 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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5GWE
 
 | cytochrome P450 CREJ | Descriptor: | (4-methylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Dong, S, liu, X, Wang, X, Feng, Y. | Deposit date: | 2016-09-11 | Release date: | 2017-07-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5GZN
 
 | Structure of neutralizing antibody bound to Zika envelope protein | Descriptor: | Antibody Heavy chain, Antibody light chain, Genome polyprotein | Authors: | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2016-09-29 | Release date: | 2016-12-28 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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6W38
 
 | Crystal structure of the FAM46C/Plk4 complex | Descriptor: | Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | Authors: | Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. | Deposit date: | 2020-03-09 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (4.48 Å) | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
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6W3J
 
 | Crystal structure of the FAM46C/Plk4/Cep192 complex | Descriptor: | Centrosomal protein of 192 kDa, Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | Authors: | Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W. | Deposit date: | 2020-03-09 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (4.385 Å) | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
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6W36
 
 | Crystal structure of FAM46C | Descriptor: | SULFATE ION, Terminal nucleotidyltransferase 5C | Authors: | Shang, G.J, Zhang, X.W, Chen, H, Lu, D.F. | Deposit date: | 2020-03-09 | Release date: | 2020-05-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.854 Å) | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
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6W3I
 
 | Crystal structure of a FAM46C mutant in complex with Plk4 | Descriptor: | Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C | Authors: | Chen, H, Shang, G.J, Lu, D.F, Zhang, X.W. | Deposit date: | 2020-03-09 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.802 Å) | Cite: | Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure, 28, 2020
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4R28
 
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4Q9V
 
 | Crystal structure of TIPE3 | Descriptor: | CHLORIDE ION, SULFATE ION, Tumor necrosis factor alpha-induced protein 8-like protein 3 | Authors: | Wu, J, Zhang, X, Chen, Y.H, Shi, Y. | Deposit date: | 2014-05-02 | Release date: | 2014-10-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell, 26, 2014
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5GZR
 
 | Zika virus E protein complexed with a neutralizing antibody Z23-Fab | Descriptor: | Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... | Authors: | Gao, G.G, Shi, Y, Peng, R, Liu, S. | Deposit date: | 2016-10-01 | Release date: | 2016-11-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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3MO2
 
 | human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 | Descriptor: | 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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4JNK
 
 | Lactate Dehydrogenase A in complex with inhibitor compound 22 | Descriptor: | (2R)-2-{[5-cyano-4-(3,4-dichlorophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)propanamide, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2013-03-15 | Release date: | 2013-05-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.896 Å) | Cite: | Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23, 2013
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3MO5
 
 | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 | Descriptor: | 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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7QXI
 
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7QWP
 
 | CryoEM structure of bacterial transcription close complex (RPc) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Ye, F.Z, Zhang, X.D. | Deposit date: | 2022-01-25 | Release date: | 2022-11-09 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanisms of DNA opening revealed in AAA+ transcription complex structures. Sci Adv, 8, 2022
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7QV9
 
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3RKD
 
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3RKC
 
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