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Crystal structure of a Glutamine-binding periplasmic protein from Burkholderia pseudomallei in complex with glutamine
Descriptor:	Glutamine-binding periplasmic protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-05-09
Release date:	2012-05-23
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structure of a Glutamine-binding periplasmic protein from Burkholderia pseudomallei in complex with glutamine To be Published

7UHB

SARS-CoV-2 spike in complex with AHB2-2GS-SB175 (local refinement of the RBD and AHB2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Multivalent miniprotein inhibitor AHB2-2GS-SB175, Spike glycoprotein
Authors:	Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2022-03-26
Release date:	2022-06-08
Last modified:	2024-05-08
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Sci Transl Med, 14, 2022

7UHC

SARS-CoV-2 spike in complex with AHB2-2GS-SB175
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Multivalent miniprotein inhibitor AHB2-2GS-SB175, ...
Authors:	Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2022-03-26
Release date:	2022-06-08
Last modified:	2024-05-08
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Sci Transl Med, 14, 2022

7N1J

Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder
Descriptor:	Binder, Fibroblast growth factor receptor 4
Authors:	Park, J.S, Lee, S.
Deposit date:	2021-05-27
Release date:	2022-04-06
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.99 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7N1K

Crystal structure of a de novo-designed mini-protein targeting FGFR
Descriptor:	Binder
Authors:	Park, J.S, Lee, S.
Deposit date:	2021-05-27
Release date:	2022-04-06
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (3.01 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

7N3T

TrkA ECD complex with designed miniprotein ligand
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Jude, K.M, Cao, L, Garcia, K.C.
Deposit date:	2021-06-01
Release date:	2022-04-20
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.84 Å)
Cite:	Design of protein-binding proteins from the target structure alone. Nature, 605, 2022

5VMR

Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.2110.4
Descriptor:	Bot.2110.4, Botulinum neurotoxin type B
Authors:	Jin, R, Lam, K, Yao, G.
Deposit date:	2017-04-28
Release date:	2017-09-20
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

5VID

Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.0671.2
Descriptor:	Bot.0671.2, Botulinum neurotoxin type B
Authors:	Jin, R, Lam, K, Yao, G.
Deposit date:	2017-04-15
Release date:	2017-09-20
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

5VLI

Computationally designed inhibitor peptide HB1.6928.2.3 in complex with influenza hemagglutinin (A/PuertoRico/8/1934)
Descriptor:	2,5,8,11-TETRAOXATRIDECANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Bernard, S.M, Wilson, I.A.
Deposit date:	2017-04-25
Release date:	2017-09-27
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.799 Å)
Cite:	Massively parallel de novo protein design for targeted therapeutics. Nature, 550, 2017

8F6Q

CryoEM structure of designed modular protein oligomer C8-71
Descriptor:	C8-71
Authors:	Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G.
Deposit date:	2022-11-17
Release date:	2023-11-29
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies Cell(Cambridge,Mass.), 187, 2024

8F6R

CryoEM structure of designed modular protein oligomer C6-79
Descriptor:	De novo designed oligomeric protein C6-79
Authors:	Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G.
Deposit date:	2022-11-17
Release date:	2023-11-29
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies Cell(Cambridge,Mass.), 187, 2024

8CUN

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in 50% d6-DMSO and 50% water with cis/trans switching (CC conformation, 50%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-05-17
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

8CWA

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in CDCl3 with cis/trans switching (TC conformation, 53%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-05-18
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

8CTO

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (B-CT conformation)
Descriptor:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-05-16
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

5KOB

Crystal structure of a peptide deformylase from Burkholderia xenovorans
Descriptor:	1,2-ETHANEDIOL, FE (II) ION, FORMIC ACID, ...
Authors:	SSGCID, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-06-30
Release date:	2016-07-13
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal structure of a peptide deformylase from Burkholderia xenovorans to be published

4EFI

Crystal Structure of 3-oxoacyl-(Acyl-carrier protein) Synthase from Burkholderia Xenovorans LB400
Descriptor:	3-oxoacyl-(Acyl-carrier protein) synthase, CHLORIDE ION, FORMIC ACID, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Craig, T.K, Abendroth, J, Staker, B, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-03-29
Release date:	2012-04-11
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.35 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

7UZL

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (B-TC conformation)
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-05-09
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBC

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in d6-DMSO with cis/trans switching
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Monteltione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBF

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in 50% d6-DMSO and 50% water with cis/trans switching (CC conformation, 50%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBD

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (A-CC conformation)
Descriptor:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UCP

computationally designed macrocycle
Descriptor:	computationally designed cyclic peptide D8.3.p2
Authors:	Bhardwaj, G, Baker, D, Rettie, S, Glynn, C, Sawaya, M.
Deposit date:	2022-03-17
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	X-RAY DIFFRACTION (0.85 Å)
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBE

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in d6-DMSO with cis/trans switching
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBI

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in CDCl3 with cis/trans switching (TT conformation, 47%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBH

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in CDCl3 with cis/trans switching
Descriptor:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBG

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (A-TT conformation)
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

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Displayed results:	25
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